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- W2078534037 abstract "Abstract A carcino-foetal antigen, identical to Gold's carcino-embryonic antigen, may be demonstrated by the immunization of rabbits with human colonic adenocarcinoma. After absorption by homologous normal tissue, the antiserum reacts with saline extracts of digestive tumours or foetal gut, but not with non-cancerous adult tissue. However, more sensitive techniques (precipitation and precipitin-inhibition reaction using perchloric extracts, immunofluorescence, radioimmunoassay) can detect small amounts of the same antigen in non-cancerous adult colon. Therefore, the carcino-embryonic antigen seems not to be cancer specific, although definite quantitative difference may be demonstrated between cancerous and non-cancerous intestine. From a practical point of view, this difference is sufficient to be useful for diagnostic purposes. In the same way, two other carcino-foetal antigens of the human digestive system, alpha-foetoprotein of hepatoma and foetal sulphoglycoprotein of gastric carcinoma, seem to have been detected where foetal or cancerous conditions do not prevail." @default.
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- W2078534037 date "1972-06-01" @default.
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- W2078534037 title "The specificity of carcino-foetal antigens of the human digestive-tract tumours" @default.
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- W2078534037 doi "https://doi.org/10.1016/0014-2964(72)90027-8" @default.
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