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- W2078534494 abstract "Basic laboratory research is the foundation of much of future clinical improvement. Critical component of basic research is to have the right animal model that mimics, as far as possible, in the human situation. Understanding the basic pathophysiology in both normal and traumatic spinal cord injury situation is the key to developing therapeutic treatments for the amelioration of impairments and the restoration of functions. In a richly organised and complex structure that is the spinal cord, promoting plasticity and repair mechanisms has proved difficult. Multiple approaches have been used and it is likely that a combination of treatments will be necessary to restore function in animal models and subsequently in humans. Key concerns are that treatments may result in abnormal nerve connections, which will actually have adverse affects on the patients’ quality of life and the concern that the use of stem cells, particularly foreign stem cells, may lead to the development of tumours. Resolving these complexities may take some time and careful clinical trials will be required to ensure the efficacy and safety of such treatments." @default.
- W2078534494 created "2016-06-24" @default.
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- W2078534494 date "2009-02-01" @default.
- W2078534494 modified "2023-09-27" @default.
- W2078534494 title "Translational research from lab to clinical practice" @default.
- W2078534494 doi "https://doi.org/10.1016/j.injury.2009.01.040" @default.
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