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• W2078541995 abstract "DDT inhibits Na channel inactivation and deactivation, promotes Na channel activation and reduces the resting potential of Xenopus oocytes expressing the Drosophila para Na channel. These changes are only marginally influenced by the single mutation M918T ( super‐kdr ) but are reduced ∼10‐fold by either the single mutation L1014F ( kdr ) or the double mutation L1014F + M918T, both of which confer resistance to the pyrethroids permethrin and deltamethrin. We conclude that DDT binds either to or in the region of L1014 on IIS6 but only weakly to M918 on the IIS4–S5 linker, which is part of a high‐affinity binding site for permethrin and deltamethrin." @default.
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• W2078541995 date "2005-10-21" @default.
• W2078541995 modified "2023-10-13" @default.
• W2078541995 title "Sensitivity of the Drosophila<i>para</i>sodium channel to DDT is not lowered by the<i>super-kdr</i>mutation M918T on the IIS4-S5 linker that profoundly reduces sensitivity to permethrin and deltamethrin" @default.
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• W2078541995 doi "https://doi.org/10.1016/j.febslet.2005.09.096" @default.
• W2078541995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16263118" @default.
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