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- W2078547753 abstract "Nucleolar organiser regions (NORs) are comprised of tandem arrays of ribosomal gene (rDNA) repeats that are transcribed by RNA polymerase I (Pol I), ultimately resulting in formation of a nucleolus. Upstream binding factor (UBF), a DNA binding protein and component of the Pol I transcription machinery, binds extensively across the rDNA repeat in vivo. Pseudo-NORs are tandem arrays of a heterologous DNA sequence with high affinity for UBF introduced into human chromosomes. In this review we describe how analysis of pseudo-NORs has provided important insights into nucleolar formation. Pseudo-NORs mimic endogenous NORs in a number of important respects. On metaphase chromosomes both appear as secondary constrictions comprised of undercondensed chromatin. The transcriptional silence of pseudo-NORs provides a platform for studying the transcription independent recruitment of factors required for nucleolar formation by this specialised chromatin structure. During interphase, pseudo-NORs appear as distinct and novel sub-nuclear bodies. Analysis of these bodies and comparison to their endogenous counterpart has provided insights into nucleolar formation and structure." @default.
- W2078547753 created "2016-06-24" @default.
- W2078547753 creator A5016223199 @default.
- W2078547753 creator A5065040262 @default.
- W2078547753 date "2008-11-01" @default.
- W2078547753 modified "2023-09-25" @default.
- W2078547753 title "Pseudo-NORs: A novel model for studying nucleoli" @default.
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- W2078547753 doi "https://doi.org/10.1016/j.bbamcr.2008.07.004" @default.
- W2078547753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18687368" @default.