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• W2078550218 startingPage "1411" @default.
• W2078550218 abstract "The concentration-activity profiles for insulin and insulin-like growth factor I (IGF-I; in the presence of and insulin-like growth factor I (IGF-I; in the presence of hydrocortisone and PRL) have been compared in terms of the accumulation of beta-casein mRNA, total casein synthesis, and alpha-lactalbumin and basal carrier-mediated glucose transport activities in mammary epithelial cells from midpregnant mice. For the accumulation of the casein mRNA and the induction of casein synthesis and alpha-lactalbumin activity, the insulin ED50 is 1-2 ng/ml, while that for IGF-I is 10- to 20-fold greater. The effects of insulin and IGF-I are not additive in these instances. For the induction of basal carrier-mediated glucose transport, the insulin ED50 is 8 ng/ml, and that for IGF-I is 16 ng/ml. Either factor can induce transport activity up to the level present in the cells from 2-day lactating mice. In this instance the effects are additive; insulin and IGF-I together can induce the transport up to the 10-day lactating level." @default.
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• W2078550218 date "1987-04-01" @default.
• W2078550218 modified "2023-10-17" @default.
• W2078550218 title "Comparison of the Roles of Insulin and Insulin-Like Growth Factor I in Casein Gene Expression and in the Development of α-Lactalbumin and Glucose Transport Activities in the Mouse Mammary Epithelial Cell" @default.
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• W2078550218 doi "https://doi.org/10.1210/endo-120-4-1411" @default.
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