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- W2078552665 abstract "We examined the effects of long-term perfusion with pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) solution on cardiac function of isolated rat hearts. Hearts were perfused with oxygenated Krebs-Henseleit (K-H) solution containing 3% PHP or hydroxyethyl starch (HES) at a constant pressure of 13 mm Hg for 24 h at 15 degrees C. After 24 h preservation, hearts were rewarmed with K-H solution. Heart rate (HR) in PHP-preserved hearts was almost the same as control and cardiac contractility was maintained at 70% of control, but coronary outflow decreased to about 50% of control. No edema developed in the PHP group. Addition of a Ca2+ antagonist, diltiazem, inhibited the elevation of the end-diastolic pressure significantly. In HES-preserved hearts, HR did not recover to control levels, but there was no significant difference in cardiac contractility between PHP- and HES-perfused hearts. The results demonstrate that isolated hearts can be preserved by perfusion with PHP solution under hypothermic conditions for 24 h and suggest that PHP solution would be useful for a perfusate of isolated organs and tissues for preservation." @default.
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- W2078552665 date "2008-11-12" @default.
- W2078552665 modified "2023-09-25" @default.
- W2078552665 title "24-Hour Preservation of Isolated Rat Hearts Perfused with Pyridoxalated Hemoglobin Polyoxyethylene Conjugate (PHP) Solution at Low Temperature" @default.
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- W2078552665 doi "https://doi.org/10.1111/j.1525-1594.1991.tb00764.x" @default.
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