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- W2078553207 abstract "Abstract Objective: To investigate in vivo effects of long‐term selective β 1 ‐blockade on cardiac energy metabolism, remodelling, function and plasma cytokines in a rat model of post‐infarct congestive heart failure (CHF). Methods: Myocardial infarction (MI) was induced in male rats by ligation of the left coronary artery. Three different groups of rats were studied, MI rats treated with metoprolol ( n =17), MI rats treated with saline ( n =14) and sham‐operated rats ( n =12). The treatment with metoprolol 1 mg/kg/h was initiated in the third week post‐infarct for a period of 6 weeks. All rats were investigated non‐invasively with volume‐selective 31 P magnetic resonance spectroscopy and echocardiography for evaluation of left ventricular (LV) energy metabolism, morphology and function. Plasma concentration of IL‐1β and IL‐6 and density of β‐adrenergic receptors were analyzed. Results: Metoprolol attenuated the increase in LV dimensions and volumes. Treatment with metoprolol had no effect on PCr/ATP and LV function. Plasma level of IL‐1β was higher and IL‐6 was lower in the metoprolol group. Density of β‐adrenergic receptors was similar in all three groups. Conclusion: Selective β 1 ‐blockade in rats with chronic CHF attenuates post‐infarct structural remodelling, without concomitant improvement in myocardial energy metabolism and function. Improvements in myocardial energy metabolism and function do not precede and are not a prerequisite for an anti‐remodelling effect of β 1 ‐blockade in the setting of chronic CHF." @default.
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- W2078553207 date "2003-12-01" @default.
- W2078553207 modified "2023-10-15" @default.
- W2078553207 title "Selective β<sub>1</sub>-blockade attenuates post-infarct remodelling without improvement in myocardial energy metabolism and function in rats with heart failure" @default.
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- W2078553207 doi "https://doi.org/10.1016/s1388-9842(03)00153-3" @default.
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