Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078553611> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2078553611 endingPage "1693" @default.
- W2078553611 startingPage "1688" @default.
- W2078553611 abstract "The most prevalent means for producing solid dispersions of nifedipine, a poorly water-soluble drug, are the solvent based processes that bring problems of environmental and health. We have investigated the preparation of solid dispersions of nifedipine (mp 173 degrees C) by the fusion method, using nicotinamide, ethylurea, polyethylene glycol (PEG) 6000 and hydroxypropylmethylcellulose (HPMC) as carriers. All these solid dispersions were obtained by cooling at room temperature after heating at 140 degrees C for 15 min. As a single carrier, nicotinamide, ethylurea and PEG were used because nifedipine dissolved in their fused liquids. Compared with the physical mixtures, the solid dispersions with ethylurea or PEG led to a higher dissolution rate of the drug, whereas the difference in drug release between the physical mixtures and the solid dispersions with nicotinamide was not clear. This peculiarity might be due to the high solubilizing effect of nicotinamide for the drug. The fused mixtures of nicotinamide-, ethylurea- or PEG-HPMC were utilized as combined carriers. HPMC dissolved in the fused liquids of nicotinamide or ethylurea, which was effective in forming the amorphous nifedipine in solid dispersions. This resulted in not only the enhanced dissolution rate but also the supersaturation behavior of nifedipine. Further, for the nicotinamide-HPMC system, the supersaturation level of nifedipine increased with an increase in the HPMC content of solid dispersions. Nicotinamide was more applicable than ethylurea and PEG for preparation of the fused dispersions of nifedipine." @default.
- W2078553611 created "2016-06-24" @default.
- W2078553611 creator A5031489265 @default.
- W2078553611 creator A5064777819 @default.
- W2078553611 date "1997-01-01" @default.
- W2078553611 modified "2023-10-16" @default.
- W2078553611 title "Comparison of Nicotinamide, Ethylurea and Polyethylene Glycol as Carriers for Nifedipine Solid Dispersion Systems." @default.
- W2078553611 doi "https://doi.org/10.1248/cpb.45.1688" @default.
- W2078553611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9353898" @default.
- W2078553611 hasPublicationYear "1997" @default.
- W2078553611 type Work @default.
- W2078553611 sameAs 2078553611 @default.
- W2078553611 citedByCount "61" @default.
- W2078553611 countsByYear W20785536112012 @default.
- W2078553611 countsByYear W20785536112013 @default.
- W2078553611 countsByYear W20785536112014 @default.
- W2078553611 countsByYear W20785536112015 @default.
- W2078553611 countsByYear W20785536112017 @default.
- W2078553611 countsByYear W20785536112019 @default.
- W2078553611 countsByYear W20785536112020 @default.
- W2078553611 countsByYear W20785536112021 @default.
- W2078553611 countsByYear W20785536112022 @default.
- W2078553611 countsByYear W20785536112023 @default.
- W2078553611 crossrefType "journal-article" @default.
- W2078553611 hasAuthorship W2078553611A5031489265 @default.
- W2078553611 hasAuthorship W2078553611A5064777819 @default.
- W2078553611 hasBestOaLocation W20785536111 @default.
- W2078553611 hasConcept C10138342 @default.
- W2078553611 hasConcept C120665830 @default.
- W2078553611 hasConcept C121332964 @default.
- W2078553611 hasConcept C162324750 @default.
- W2078553611 hasConcept C177562468 @default.
- W2078553611 hasConcept C178790620 @default.
- W2078553611 hasConcept C181199279 @default.
- W2078553611 hasConcept C185592680 @default.
- W2078553611 hasConcept C200447597 @default.
- W2078553611 hasConcept C2776964284 @default.
- W2078553611 hasConcept C2779066535 @default.
- W2078553611 hasConcept C2779728014 @default.
- W2078553611 hasConcept C2781011878 @default.
- W2078553611 hasConcept C43617362 @default.
- W2078553611 hasConcept C519063684 @default.
- W2078553611 hasConcept C54400483 @default.
- W2078553611 hasConcept C88380143 @default.
- W2078553611 hasConceptScore W2078553611C10138342 @default.
- W2078553611 hasConceptScore W2078553611C120665830 @default.
- W2078553611 hasConceptScore W2078553611C121332964 @default.
- W2078553611 hasConceptScore W2078553611C162324750 @default.
- W2078553611 hasConceptScore W2078553611C177562468 @default.
- W2078553611 hasConceptScore W2078553611C178790620 @default.
- W2078553611 hasConceptScore W2078553611C181199279 @default.
- W2078553611 hasConceptScore W2078553611C185592680 @default.
- W2078553611 hasConceptScore W2078553611C200447597 @default.
- W2078553611 hasConceptScore W2078553611C2776964284 @default.
- W2078553611 hasConceptScore W2078553611C2779066535 @default.
- W2078553611 hasConceptScore W2078553611C2779728014 @default.
- W2078553611 hasConceptScore W2078553611C2781011878 @default.
- W2078553611 hasConceptScore W2078553611C43617362 @default.
- W2078553611 hasConceptScore W2078553611C519063684 @default.
- W2078553611 hasConceptScore W2078553611C54400483 @default.
- W2078553611 hasConceptScore W2078553611C88380143 @default.
- W2078553611 hasIssue "10" @default.
- W2078553611 hasLocation W20785536111 @default.
- W2078553611 hasLocation W20785536112 @default.
- W2078553611 hasOpenAccess W2078553611 @default.
- W2078553611 hasPrimaryLocation W20785536111 @default.
- W2078553611 hasRelatedWork W1974213314 @default.
- W2078553611 hasRelatedWork W2035384210 @default.
- W2078553611 hasRelatedWork W2068143976 @default.
- W2078553611 hasRelatedWork W2068593233 @default.
- W2078553611 hasRelatedWork W2078553611 @default.
- W2078553611 hasRelatedWork W2130111275 @default.
- W2078553611 hasRelatedWork W2366838512 @default.
- W2078553611 hasRelatedWork W2393149174 @default.
- W2078553611 hasRelatedWork W2444238295 @default.
- W2078553611 hasRelatedWork W2183972346 @default.
- W2078553611 hasVolume "45" @default.
- W2078553611 isParatext "false" @default.
- W2078553611 isRetracted "false" @default.
- W2078553611 magId "2078553611" @default.
- W2078553611 workType "article" @default.