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- W2078554471 abstract "Anti-HIV bioassay-guided fractionation of an organic extract of Ochanostachys amentacea provided an HIV-inhibitory polyacetylenic acid. The identity of this compound was established as (-)-17-hydroxy-9,11,13,15-octadecatetraynoic acid (1), also known as minquartynoic acid, by comparison of its physical and spectral data with previously reported values. Analysis of Mosher's ester derivatives of the methyl ester of 1 allowed assignment of S absolute stereochemistry to the lone chiral center. In an in vitro XTT-based anti-HIV assay, 2-5 micrograms/mL of minquartynoic acid (1) effectively inhibited human lymphoblastoid cell killing by HIV-1." @default.
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- W2078554471 date "2001-01-01" @default.
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- W2078554471 title "Absolute Stereochemistry and Anti-HIV Activity of Minquartynoic Acid, A Polyacetylene from<i>Ochanostachys amentacea</i><sup>1a</sup>" @default.
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- W2078554471 doi "https://doi.org/10.1080/10575630108041253" @default.
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