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- W2078554997 abstract "Abstract The effects of a C 14 polyacetylenic tetrahydropyranyl alcohol and its acetate ester—the active principles of the leaves of Clibadium sylvestre which are used by South American Indians as a fish poison—have been studied on the oxidative phosphorylation of rat liver mitochondria. Preincubation of rat liver mitochondria with these compounds caused a fall in the P/O ratio and respiratory control of the mitochondria when oxidizing β-hydroxybuty-rate, succinate, pyruvate and malate, and isocitrate. With all substrates, the state III (stimulated) respiration fell by at least 20 per cent after a few minutes preincubation with the polyacetylenic compounds. By contrast the state IV (resting) respiration was not markedly affected except when β-hydroxy-butyrate was the substrate. Both compounds were found to inhibit, linearly with concentration, the ATP-Mg 2+ induced contraction of mitochondria swollen by inorganic phosphate. Complete inhibition of contraction occurred at a final concentration of 15 × 10 −5 M for the poly-acetylenic alcohol and 12 × 10 −5 M for the acetate ester. Derivatives of these compounds in which the polyacetylenic chain had been partially or fully saturated did not uncouple oxidative phosphorylation. These derivatives also only partially inhibit the ATP-Mg 2+ induced contraction of swollen mitochondria. The results are discussed with respect to configuration of these compounds and the structure and function of the mitochondrial membrane." @default.
- W2078554997 created "2016-06-24" @default.
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- W2078554997 date "1969-01-01" @default.
- W2078554997 modified "2023-09-27" @default.
- W2078554997 title "Effect of a polyacetylenic fish poison on the oxidative phosphorylation of rat liver mitochondria" @default.
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- W2078554997 doi "https://doi.org/10.1016/0006-2952(69)90011-2" @default.
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