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• W2078556329 abstract "Bacterial small non-coding RNAs act as important regulators that control numerous cellular processes. Here we identified RaoN, a novel small RNA encoded in the cspH-envE intergenic region on Salmonella pathogenicity island-11 (SPI-11). RaoN contributes to survival under conditions of acid and oxidative stress combined with nutrient limitation, which partially mimic the intramacrophage environment. Indeed, inactivation of raoN reduces the intramacrophage replication of Salmonella enterica serovar Typhimurium. Genome-wide transcriptome analysis revealed that the lactate dehydrogenase gene ldhA is upregulated in the raoN knockout mutant. Notably, both inactivation and overexpression of ldhA in the WT strain render Salmonella more sensitive to oxidative stress, particularly when combined with nutrient limitation. However, ldhA is not the sole determinant of RaoN function in facilitating intramacrophage survival of Salmonella. Together, our data suggest that balanced regulation of ldhA expression by RaoN is necessary for survival under in vitro stress conditions and contributes to the intramacrophage growth of Salmonella." @default.
• W2078556329 created "2016-06-24" @default.
• W2078556329 creator A5010094971 @default.
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• W2078556329 creator A5091149206 @default.
• W2078556329 date "2013-07-01" @default.
• W2078556329 modified "2023-10-14" @default.
• W2078556329 title "RaoN, a small RNA encoded within Salmonella pathogenicity island-11, confers resistance to macrophage-induced stress" @default.
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• W2078556329 doi "https://doi.org/10.1099/mic.0.066688-0" @default.
• W2078556329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3749724" @default.
• W2078556329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23657681" @default.
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