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- W2078556521 endingPage "99" @default.
- W2078556521 startingPage "84" @default.
- W2078556521 abstract "A consequence of normal aging is a greater susceptibility to memory impairments following an immune challenge such as infection, surgery, or traumatic brain injury. The neuroinflammatory response, produced by these challenges results in increased and prolonged production of pro-inflammatory cytokines in the otherwise healthy aged brain. Here we discuss the mechanisms by which long-lasting elevations in pro-inflammatory cytokines in the hippocampus produce memory impairments. Sensitized microglia are a primary source of this exaggerated neuroinflammatory response and appear to be a hallmark of the normal aging brain. We review the current understanding of the causes and effects of normal aging-induced microglial sensitization, including dysregulations of the neuroendocrine system, potentiation of neuroinflammatory responses following an immune challenge, and the impairment of memories. We end with a discussion of therapeutic approaches to prevent these deleterious effects." @default.
- W2078556521 created "2016-06-24" @default.
- W2078556521 creator A5011957342 @default.
- W2078556521 creator A5025282582 @default.
- W2078556521 creator A5025859087 @default.
- W2078556521 creator A5041777589 @default.
- W2078556521 date "2015-11-01" @default.
- W2078556521 modified "2023-10-14" @default.
- W2078556521 title "Neuroinflammation in the normal aging hippocampus" @default.
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