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- W2078556968 abstract "The properties of the autonomically regulated chloride current (ICl) were studied in isolated guinea pig ventricular myocytes. This current was elicited upon exposure to isoproterenol (ISO) and reversed upon concurrent exposure to acetylcholine (ACh). ICl was time independent and exhibited outward rectification. The responses to ISO and ACh could be blocked by propranolol and atropine, respectively, and ICl was also elicited by forskolin, 8-bromoadenosine 3',5'-cyclic monophosphate, and 3-isobutyl-l-methylxanthine, indicating that the current is regulated through a cAMP-dependent pathway. The reversal potential of the ISO-induced current followed the predicted chloride equilibrium potential, consistent with it being carried predominantly by Cl-. Activation of ICl produced changes in the resting membrane potential and action potential duration, which were Cl- gradient dependent. These results indicate that under physiological conditions ICl may play an important role in regulating action potential duration and resting membrane potential in mammalian cardiac myocytes." @default.
- W2078556968 created "2016-06-24" @default.
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- W2078556968 creator A5066498895 @default.
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- W2078556968 date "1990-06-01" @default.
- W2078556968 modified "2023-10-03" @default.
- W2078556968 title "Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential." @default.
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- W2078556968 doi "https://doi.org/10.1085/jgp.95.6.1077" @default.
- W2078556968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2216356" @default.
- W2078556968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2165130" @default.
- W2078556968 hasPublicationYear "1990" @default.
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