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- W2078558764 abstract "Insulinoma tissue in vitro in the presence of glucose and labeled leucine synthesizes both proinsulin and insulin and releases these hormones into the medium. DAMP (N6-O2-dibutyryl-adenosine-3′,5′-cyclic phosphate) and theophylline have been shown to enhance the release of labeled proinsulin and insulin from the tissue. After a 1-hr “chase” experiment, only labeled insulin and a partially cleaved intermediate of proinsulin were shown to be present both in the tissue and in the medium. Thus, all previously labeled proinsulin had been converted either to an intermediate form or to insulin. Trypsin treatment of the intermediate form produces material that migrates as insulin and C peptide on polyacrylamide electrophoresis. Following iv tolbutamide, plasma obtained from this insulinoma patient showed that the major portion of the insulin was “big insulin.” Present evidence favors the identity of “big insulin” and proinsulin. These results suggest that certain insulinomas are capable of releasing large amounts of proinsulin, intermediates of proinsulin and insulin into the circulation." @default.
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- W2078558764 date "1970-03-01" @default.
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- W2078558764 title "Synthesis and Release of Proinsulin and Insulin by Human Insulinoma Tissue" @default.
- W2078558764 doi "https://doi.org/10.1210/jcem-30-3-273" @default.
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