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- W2078561615 abstract "The 5-HT-induced shape change and subsequent aggregation of platelets provides a functional assay for 5-HT2 receptors. In the present study we describe a method to increase aggregometer sensitivity by digital conversion of the voltage produced by changes in light transmirtance through a platelet suspension, thereby allowing accurate analyses of the primary shape-change response. The pharmacology of 5-HT-induced shape change was then compared with that of [I]-iodoLSD binding in human platelets. 5-HT caused a dose-dependent change in platelet shape (maximum response 5 × 10–6 M, EC50 10–6 M). Furthermore, there was a significant correlation across a selection of drugs between IC50 values for inhibition of 5-HT-induced shape change and for inhibition of platelet binding of the 5-HT2 receptor ligand [I]-iodoLSD. These results support the hypothesis that 5-HT-induced shape change and [I]-iodoLSD binding in human platelets are mediated through the same receptor, and validate the methods of data acquisition described." @default.
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- W2078561615 date "1991-02-01" @default.
- W2078561615 modified "2023-10-16" @default.
- W2078561615 title "5-Hydroxytryptamine (5-HT)-induced shape change in human platelets determined by computerized data acquisition" @default.
- W2078561615 doi "https://doi.org/10.1097/00001721-199102000-00003" @default.
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