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• W2078562730 abstract "IntroductionThe surface-associated collagen-binding protein Ace of Enterococcus faecalis has been implicated as a virulence factor that contributes to bacterial persistence in endodontic infections. The purpose of this study was to determine if proteins with amino acid sequence similarity to Ace found in more abundant oral streptococci could play a similar role in potentially enhancing endodontic infections.MethodsA Streptococcus gordonii gene similar to ace was identified by genome sequence searches in silico. An isogenic derivative of strain DL1 with a disruption in the identified gene was constructed by allelic replacement. Parent and mutant strains were characterized for their ability to bind immobilized collagen type 1 in a microtiter plate-binding assay. Survival of the strains in a human tooth ex vivo–instrumented root canal model was compared by inoculating canals with parental or mutant bacteria and determining the colony-forming units (CFUs) recovered at various time points over a 12-day period.ResultsThe S. gordonii gene, encoding a protein with a conserved collagen-binding domain similar to that of Ace, was designated cbdA. The cbdA-deficient cells were less able to bind collagen type 1 than parental cells (P < .0001). Genetic complementation of the cbdA-deficient strain restored the collagen-binding phenotype. By day 12, significantly fewer (P = .03) cbdA-deficient than parental CFUs were recovered from instrumented canals.ConclusionsA gene encoding a putative collagen-binding protein was identified in S. gordonii. Fewer S. gordonii cbdA–deficient cells survived ex vivo compared with parental cells, suggesting that collagen-binding proteins may contribute to the persistence of oral streptococci in instrumented root canals." @default.
• W2078562730 created "2016-06-24" @default.
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• W2078562730 date "2013-01-01" @default.
• W2078562730 modified "2023-10-12" @default.
• W2078562730 title "Streptococcus gordonii Collagen-binding Domain Protein CbdA May Enhance Bacterial Survival in Instrumented Root Canals Ex Vivo" @default.
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• W2078562730 doi "https://doi.org/10.1016/j.joen.2012.06.002" @default.
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