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- W2078563894 abstract "Background: The aim of this study was to investigate the use of imaging techniques to predict the response to cardiac resynchronization therapy (CRT) in patients with non-ischemic cardiomyopathy (NICM) by simultaneous assessment of left ventricular (LV) dyssynchrony and myocardial perfusion in a single nuclear scan of the heart. Methods: Patients indicated for CRT device implantation underwent a resting myocardial perfusion assessment with single photon emission computed tomography (MP-SPECT) examination using technetium-99 m methoxyisobutylisonitrile prior to device implantation. CardioGRAF and cardioBull software (FUJIFILM RI Pharma, Tokyo, Japan) were used to analyze the LV mechanical dyssynchrony and myocardial viability, respectively. Patient follow-ups were performed at 6 months after device implantation. CRT response was defined as a Z 10% decrease in the LV end systolic volume. Results: A total of 43 patients with NICM were analyzed. Using the cutoff points of 6.2 for the dyssynchrony index and 66% for LV myocardial perfusion, the combined indices predicted CRT response with a sensitivity of 77.8% and specificity of 91.2%. Conclusion: Combined assessment of MP-SPECT and a measure of LV mechanical dyssynchrony showed good predictive ability in patients with non-ischemic heart failure." @default.
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- W2078563894 date "2010-03-01" @default.
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- W2078563894 title "DETECTION OF REGIONAL LOW MYOCARDIAL PERFUSION HELPS PREDICT A RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY IN PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY:FIND INDEX BY NUCLEAR IMAGING FOR DYSSYNCHRONY (FIND) STUDY" @default.
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- W2078563894 doi "https://doi.org/10.1016/s0735-1097(10)60226-4" @default.
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