FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078565478> ?p ?o ?g. }

• W2078565478 endingPage "365" @default.
• W2078565478 startingPage "359" @default.
• W2078565478 abstract "Psoriasis is a chronic inflammatory disease with a complex genetic architecture. To further advance gene discovery, we extended our genome-wide association study data set of 1,139 cases and 2,234 controls and replicated two independent cohorts of 7,200 cases and 10,491 controls. We identified the missense variant rs2303138 (p.Ala763Thr) within the LNPEP gene associated with psoriasis (Pcombined=1.83 × 10(-13), odds ratio=1.16) and validated four previously reported genes: IL28RA, NFKBIA, TRAF3IP2, and CARD14 (9.74 × 10(-11)P9.37 × 10(-5)), which confirmed the involvement of the nuclear factor-κB signaling pathway in psoriasis pathogenesis. LNPEP, also named insulin-responsive aminopeptidase, was identified as an angiotensin IV receptor. Protein function prediction suggested that this missense variant of LNPEP was most likely deleterious. Expression analysis showed that LNPEP was significantly downregulated in psoriatic lesions compared with the control skin (P=1.44 × 10(-6)) and uninvolved patient skin (P=2.95 × 10(-4)). Pathway analysis indicated that LNPEP was involved in the renin-angiotensin system, which also has a key role in cardiovascular disease and diabetes. These results provided genetic evidence that psoriasis might share common mechanisms with hypertension and diabetes, which was consistent with clinical observations. Our study identified a genetic susceptibility factor and provided genetic evidence of insight into psoriasis pathogenesis with the involvement of the renin-angiotensin system pathway." @default.
• W2078565478 created "2016-06-24" @default.
• W2078565478 creator A5001699296 @default.
• W2078565478 creator A5002356988 @default.
• W2078565478 creator A5003515738 @default.
• W2078565478 creator A5003941959 @default.
• W2078565478 creator A5004418207 @default.
• W2078565478 creator A5012350468 @default.
• W2078565478 creator A5016398433 @default.
• W2078565478 creator A5017210235 @default.
• W2078565478 creator A5027749624 @default.
• W2078565478 creator A5027849828 @default.
• W2078565478 creator A5028805559 @default.
• W2078565478 creator A5029797911 @default.
• W2078565478 creator A5032692636 @default.
• W2078565478 creator A5034325669 @default.
• W2078565478 creator A5035282947 @default.
• W2078565478 creator A5035586725 @default.
• W2078565478 creator A5036705619 @default.
• W2078565478 creator A5039496582 @default.
• W2078565478 creator A5040390300 @default.
• W2078565478 creator A5040577934 @default.
• W2078565478 creator A5070407653 @default.
• W2078565478 creator A5072004274 @default.
• W2078565478 creator A5075460531 @default.
• W2078565478 creator A5081159076 @default.
• W2078565478 creator A5083506982 @default.
• W2078565478 creator A5088141052 @default.
• W2078565478 creator A5088669697 @default.
• W2078565478 creator A5090846305 @default.
• W2078565478 date "2014-02-01" @default.
• W2078565478 modified "2023-10-16" @default.
• W2078565478 title "Identification of a Missense Variant in LNPEP that Confers Psoriasis Risk" @default.
• W2078565478 cites W1622532022 @default.
• W2078565478 cites W1964995490 @default.
• W2078565478 cites W1973717482 @default.
• W2078565478 cites W2003959542 @default.
• W2078565478 cites W2007724949 @default.
• W2078565478 cites W2013173751 @default.
• W2078565478 cites W2020906240 @default.
• W2078565478 cites W2027847170 @default.
• W2078565478 cites W2029292942 @default.
• W2078565478 cites W2033342396 @default.
• W2078565478 cites W2037981154 @default.
• W2078565478 cites W2038309633 @default.
• W2078565478 cites W2045113343 @default.
• W2078565478 cites W2049572499 @default.
• W2078565478 cites W2052383963 @default.
• W2078565478 cites W2054684876 @default.
• W2078565478 cites W2055577456 @default.
• W2078565478 cites W2057448387 @default.
• W2078565478 cites W2059145105 @default.
• W2078565478 cites W2102889851 @default.
• W2078565478 cites W2105842551 @default.
• W2078565478 cites W2107328434 @default.
• W2078565478 cites W2108169091 @default.
• W2078565478 cites W2110888991 @default.
• W2078565478 cites W2114701953 @default.
• W2078565478 cites W2119504375 @default.
• W2078565478 cites W2126930838 @default.
• W2078565478 cites W2132193621 @default.
• W2078565478 cites W2133465414 @default.
• W2078565478 cites W2142459107 @default.
• W2078565478 cites W2144265655 @default.
• W2078565478 cites W2145527655 @default.
• W2078565478 cites W2149335113 @default.
• W2078565478 cites W2155799313 @default.
• W2078565478 cites W2157752701 @default.
• W2078565478 cites W2158217645 @default.
• W2078565478 cites W2168521098 @default.
• W2078565478 cites W4294216483 @default.
• W2078565478 doi "https://doi.org/10.1038/jid.2013.317" @default.
• W2078565478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23897274" @default.
• W2078565478 hasPublicationYear "2014" @default.
• W2078565478 type Work @default.
• W2078565478 sameAs 2078565478 @default.
• W2078565478 citedByCount "46" @default.
• W2078565478 countsByYear W20785654782014 @default.
• W2078565478 countsByYear W20785654782015 @default.
• W2078565478 countsByYear W20785654782016 @default.
• W2078565478 countsByYear W20785654782017 @default.
• W2078565478 countsByYear W20785654782018 @default.
• W2078565478 countsByYear W20785654782019 @default.
• W2078565478 countsByYear W20785654782020 @default.
• W2078565478 countsByYear W20785654782021 @default.
• W2078565478 countsByYear W20785654782022 @default.
• W2078565478 countsByYear W20785654782023 @default.
• W2078565478 crossrefType "journal-article" @default.
• W2078565478 hasAuthorship W2078565478A5001699296 @default.
• W2078565478 hasAuthorship W2078565478A5002356988 @default.
• W2078565478 hasAuthorship W2078565478A5003515738 @default.
• W2078565478 hasAuthorship W2078565478A5003941959 @default.
• W2078565478 hasAuthorship W2078565478A5004418207 @default.
• W2078565478 hasAuthorship W2078565478A5012350468 @default.
• W2078565478 hasAuthorship W2078565478A5016398433 @default.
• W2078565478 hasAuthorship W2078565478A5017210235 @default.
• W2078565478 hasAuthorship W2078565478A5027749624 @default.
• W2078565478 hasAuthorship W2078565478A5027849828 @default.

• next