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- W2078572000 abstract "Pseudomonas aeruginosa is ubiquitously present in the environment and acts as an opportunistic pathogen on humans, animals and plants. We report here the effects of the prebiotic polysaccharide inulin and its hydrolysed form FOS on this bacterium. FOS was found to inhibit bacterial growth of strain PAO1, while inulin did not affect growth rate or yield in a significant manner. Inulin stimulated biofilm formation, whereas a dramatic reduction of the biofilm formation was observed in the presence of FOS. Similar opposing effects were observed for bacterial motility, where FOS inhibited the swarming and twitching behaviour whereas inulin caused its stimulation. In co-cultures with eukaryotic cells (macrophages) FOS and, to a lesser extent, inulin reduced the secretion of the inflammatory cytokines IL-6, IL-10 and TNF-α. Western blot experiments indicated that the effects mediated by FOS in macrophages are associated with a decreased activation of the NF-κB pathway. Since FOS and inulin stimulate pathway activation in the absence of bacteria, the FOS mediated effect is likely to be of indirect nature, such as via a reduction of bacterial virulence. Further, this modulatory effect is observed also with the highly virulent ptxS mutated strain. Co-culture experiments of P. aeruginosa with IEC18 eukaryotic cells showed that FOS reduces the concentration of the major virulence factor, exotoxin A, suggesting that this is a possible mechanism for the reduction of pathogenicity. The potential of these compounds as components of antibacterial and anti-inflammatory cocktails is discussed." @default.
- W2078572000 created "2016-06-24" @default.
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- W2078572000 date "2014-01-22" @default.
- W2078572000 modified "2023-10-16" @default.
- W2078572000 title "Fructooligosacharides Reduce Pseudomonas aeruginosa PAO1 Pathogenicity through Distinct Mechanisms" @default.
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- W2078572000 cites W1967239401 @default.
- W2078572000 cites W1973516496 @default.
- W2078572000 cites W1976153567 @default.
- W2078572000 cites W1976455344 @default.
- W2078572000 cites W1978046264 @default.
- W2078572000 cites W1981764881 @default.
- W2078572000 cites W1990652438 @default.
- W2078572000 cites W1995676605 @default.
- W2078572000 cites W1995707731 @default.
- W2078572000 cites W1996269321 @default.
- W2078572000 cites W1998350370 @default.
- W2078572000 cites W2000461931 @default.
- W2078572000 cites W2012615744 @default.
- W2078572000 cites W2013583403 @default.
- W2078572000 cites W2013611006 @default.
- W2078572000 cites W2016158447 @default.
- W2078572000 cites W2021126639 @default.
- W2078572000 cites W2021922484 @default.
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- W2078572000 cites W2026263963 @default.
- W2078572000 cites W2028604981 @default.
- W2078572000 cites W2029776332 @default.
- W2078572000 cites W2030074619 @default.
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- W2078572000 cites W2039780924 @default.
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- W2078572000 cites W2055165205 @default.
- W2078572000 cites W2057291237 @default.
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- W2078572000 cites W2066202199 @default.
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- W2078572000 cites W2085347581 @default.
- W2078572000 cites W2087631877 @default.
- W2078572000 cites W2093995195 @default.
- W2078572000 cites W2097293600 @default.
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- W2078572000 cites W2143398242 @default.
- W2078572000 cites W2149014115 @default.
- W2078572000 cites W2149908911 @default.
- W2078572000 cites W2150081979 @default.
- W2078572000 cites W2150927592 @default.
- W2078572000 cites W2152344036 @default.
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- W2078572000 cites W2162237022 @default.
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- W2078572000 cites W2410221258 @default.
- W2078572000 cites W4240233279 @default.
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- W2078572000 doi "https://doi.org/10.1371/journal.pone.0085772" @default.
- W2078572000 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3899050" @default.
- W2078572000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24465697" @default.
- W2078572000 hasPublicationYear "2014" @default.
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