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- W2078577105 endingPage "1471" @default.
- W2078577105 startingPage "1468" @default.
- W2078577105 abstract "A glucose-sensitive insulin-releasing protein device was synthesized by connecting insulin to glucose oxidase (GOD) through a disulfide linkage. Insulin was released from the device by reductive cleavage of the disulfide linkage with electrons generated upon oxidation of glucose by GOD. Some protein devices containing different amounts of insulin were synthesized by varying the feed concentration in the synthetic process. The amount of released insulin increased with the increase of insulin content in the protein device. Although using urea enhanced the amount of insulin coupled to GOD, the efficiency of insulin release did not increase. The fluorescence quenching of the protein device containing fluorescence-labelled insulin with acrylamide showed that insulin was incorporated into the interior domain of the GOD molecule by addition of urea." @default.
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- W2078577105 date "1994-05-01" @default.
- W2078577105 modified "2023-10-18" @default.
- W2078577105 title "Synthesis of Glucose-Sensitive Insulin-Releasing Protein Devices" @default.
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- W2078577105 doi "https://doi.org/10.1246/bcsj.67.1468" @default.
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