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• W2078577907 startingPage "92" @default.
• W2078577907 abstract "Relapsing-remitting experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model, is induced in mice by injection of myelin proteolipid protein (PLP) encephalitogenic peptide, PLP139-151, in adjuvant. In this study, prior to EAE induction, mice were vaccinated with a bacterial plasmid encoding a PLP-ubiquitin fusion (pCMVUPLP). During the relapse phase of EAE, clinical signs, histopathologic changes, in vitro lymphoproliferation to PLP139-151 and interferon-gamma levels were reduced in pCMVUPLP-vaccinated mice, compared to mock-vaccinated mice (controls). Lymphocytes from pCMVUPLP-vaccinated mice produced interleukin-4, a cytokine lacking in controls. Thus, pCMVUPLP vaccination can modulate the relapse after EAE induction." @default.
• W2078577907 created "2016-06-24" @default.
• W2078577907 creator A5004022737 @default.
• W2078577907 creator A5004132688 @default.
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• W2078577907 creator A5074673340 @default.
• W2078577907 creator A5075220882 @default.
• W2078577907 date "2008-11-15" @default.
• W2078577907 modified "2023-10-18" @default.
• W2078577907 title "Targeting myelin proteolipid protein to the MHC class I pathway by ubiquitination modulates the course of experimental autoimmune encephalomyelitis" @default.
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