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- W2078578479 abstract "Vasoactive intestinal peptide (VIP), a neuropeptide present in primary and secondary lymphoid organs has been previously reported to inhibit IL-2 and IL-4 production, as well as the proliferation of mitogen- or antigen-stimulated T-cells. Binding studies suggested that the immunoregulatory effects of VIP are mediated through specific VIP-binding sites present on lymphocyte subpopulations. Here we report on the expression of VIP-R1 mRNA in various murine lymphocyte subpopulations. By using RT-PCR, RNase protection assay, cDNA cloning, and sequence analysis, we show that stimulated and unstimulated murine spleen cells, thymocytes, CD4+ and CD8+ T-cells express VIP-R1. The VIP-R1 fragment amplified from murine brain, thymocytes, spleen cells and CD4+ T-cells share identical nucleotide sequences, and a high degree of homology with the corresponding nonlymphoid rat and human VIP-R1 sequences. The expression of VIP-R1 in thymocytes and peripheral lymphocytes, and especially in the CD4+ T-cell subset supports the idea that VIP produced or released locally in the lymphoid microenvironment could directly affect cytokine production and proliferation of T-lymphocytes." @default.
- W2078578479 created "2016-06-24" @default.
- W2078578479 creator A5003137056 @default.
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- W2078578479 date "1996-08-01" @default.
- W2078578479 modified "2023-10-02" @default.
- W2078578479 title "Murine T-lymphocytes express vasoactive intestinal peptide receptor 1 (VIP-R1) mRNA" @default.
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- W2078578479 doi "https://doi.org/10.1016/0165-5728(96)00085-9" @default.
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