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- W2078583719 abstract "The incidence of Alzheimer's disease (AD) is increasing. Thus; new and improved diagnostic tools are needed. The search for prospective biomarkers to support the existing diagnostic methods is intense but a clear-cut protein signature remains elusive. The objective of this study was to quantify 20 analytes per sample using the Luminex technology, aiming to develop a screening method to be applied in the early stage of disease progression. Here we report measurements of cerebrospinal fluid (CSF) and serum samples from a pilot study. The results suggest a three-marker panel as a putative diagnostic tool for Alzheimer's disease. Thirty patients clinically diagnosed with Alzheimer's disease, six healthy controls and ten patients with mild cognitive impairment were included. CSF and serum were obtained from each individual. Concentrations of proteins in CSF and serum were determined using a multianalyte sandwich immunoassay, developed on the Luminex platform, essentially as described by Skogstrand et al. 2005. Analytes of interest were chosen after literature studies, in particular Ray et al. 2007. Not all of the 20 analytes could be measured in both CSF and serum. However, interleukin-3 (IL-3), interleukin-11(IL-11) and macrophage inflammatory protein-1 delta (MIP-1δ) were significantly increased in the serum samples of AD compared to the controls, with p- values of 0.017, 0.041 and 0.038 respectively. Albeit not significantly different from either group the values of the MCI samples showed an increasing trend and were intermediate between the control and the AD group. In CSF, IL-3 was decreased in AD compared to controls with a p-value of 0.041. An IL-3 ratio comparison between serum and CSF gave a significant p-value of 0.012. IL-3 may be an attractive biomarker candidate and is also integrated in the 5-protein biomarker signature presented by Ravetti and Moscato 2008 extracted from Ray et al. 2007. Additionally, and although further investigation is needed, determination of significantly increased serum levels of IL-3, IL-11 and MIP-1δ in this study, indicates that these three cytokines are putative biomarkers for Alzheimer's disease in blood samples." @default.
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- W2078583719 date "2010-07-01" @default.
- W2078583719 modified "2023-09-27" @default.
- W2078583719 title "P4-047: Putative Biomarkers for Alzheimer's Disease; Interleukin- 3, Interleukin-11 and Macrophage Inflammatory Protein-1 Delta In Serum And Cerebrospinal Fluid" @default.
- W2078583719 doi "https://doi.org/10.1016/j.jalz.2010.08.107" @default.
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