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- W2078585951 abstract "To clarify the metabolism of PGE2, prostacyclin (PGI2) and thromboxane A2(TxA2) in small vessels in spontaneously hypertensive rats (SHR), we removed superior mesenteric vascular beds from 10 week old SHR and age matched normotensive controls (WKY). The mesenteric artery was perfused with Krebs-Henseleit buffer and samples of effluent collected every 15 minutes during 3 hours perfussion or analysis of PGE2, 6-keto-PGF1α (a stable metabolite of PGI2) and TxB2 (a stable metabolite of TxA2) by specific radioimmunoassays. Levels of all three arachidonic acid (AA) metabolites, PGE2, 6-keto-PGF1α and TxB2, in the mesenteric effluent were significantly reduced in SHR as compared to WKY. TxB2 was detected in all samples throughout the perfusion. 6-keto-PGF1α/PGE2 ratios and TxB2/PGE2 ratios were significantly increased in SHR. 6-keto-PGF1α/TxB2 ratios in the first four samples were significantly decreased in SHR as compared to WKY. These data suggest that there may be reduced availability of PG precusor AA and unbalanced synthesis of PGs in small vessels in SHR. Both may have relevance to the development of hypertension in the animals." @default.
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- W2078585951 date "1985-02-01" @default.
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- W2078585951 title "Prostaglandins and thromboxane outflow from the perfused mesenteric vascular bed in spontaneously hypertensive rats" @default.
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- W2078585951 doi "https://doi.org/10.1016/0090-6980(85)90212-6" @default.
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