FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078585966> ?p ?o ?g. }

• W2078585966 endingPage "C305" @default.
• W2078585966 startingPage "C295" @default.
• W2078585966 abstract "In the current study, we examined whether diabetes affected the ability of HDL to stimulate nitric oxide (NO) production. Using HDL isolated from both diabetic humans and diabetic mouse models, we found that female HDL no longer induced NO synthesis, despite containing equivalent amounts of estrogen as nondiabetic controls. Furthermore, HDL isolated from diabetic females and males prevented acetylcholine-induced stimulation of NO generation. Analyses of both the human and mouse diabetic HDL particles showed that the HDLs contained increased levels of myristic acid. To determine whether myristic acid associated with HDL particles was responsible for the decrease in NO generation, myristic acid was added to HDL isolated from nondiabetic humans and mice. Myristic acid-associated HDL inhibited the generation of NO in a dose-dependent manner. Importantly, diabetic HDL did not alter the levels of endothelial NO synthase or acetylcholine receptors associated with the cells. Surprisingly, diabetic HDL inhibited ionomycin-induced stimulation of NO production without affecting ionomycin-induced increases in intracellular calcium. Further analysis indicated that diabetic HDL prevented calmodulin from interacting with endothelial NO synthase (eNOS) but did not affect the activation of calmodulin kinase or calcium-independent mechanisms for stimulating eNOS. These studies are the first to show that a specific fatty acid associated with HDL inhibits the stimulation of NO generation. These findings have important implications regarding cardiovascular disease in diabetic patients." @default.
• W2078585966 created "2016-06-24" @default.
• W2078585966 creator A5000241718 @default.
• W2078585966 creator A5006269031 @default.
• W2078585966 creator A5010366988 @default.
• W2078585966 creator A5011493936 @default.
• W2078585966 creator A5026164472 @default.
• W2078585966 creator A5044742086 @default.
• W2078585966 creator A5058670897 @default.
• W2078585966 creator A5060222207 @default.
• W2078585966 creator A5070818874 @default.
• W2078585966 creator A5083251487 @default.
• W2078585966 creator A5084108232 @default.
• W2078585966 creator A5084519057 @default.
• W2078585966 creator A5091187358 @default.
• W2078585966 date "2008-01-01" @default.
• W2078585966 modified "2023-10-18" @default.
• W2078585966 title "Diabetic HDL-associated myristic acid inhibits acetylcholine-induced nitric oxide generation by preventing the association of endothelial nitric oxide synthase with calmodulin" @default.
• W2078585966 cites W1543022249 @default.
• W2078585966 cites W1574380753 @default.
• W2078585966 cites W1576930851 @default.
• W2078585966 cites W1588516858 @default.
• W2078585966 cites W1802119609 @default.
• W2078585966 cites W1965983458 @default.
• W2078585966 cites W1967357406 @default.
• W2078585966 cites W1971536285 @default.
• W2078585966 cites W1994506978 @default.
• W2078585966 cites W1996890444 @default.
• W2078585966 cites W1998240747 @default.
• W2078585966 cites W1999559291 @default.
• W2078585966 cites W2008331846 @default.
• W2078585966 cites W2032138803 @default.
• W2078585966 cites W2038266874 @default.
• W2078585966 cites W2047057336 @default.
• W2078585966 cites W2051134788 @default.
• W2078585966 cites W2057190489 @default.
• W2078585966 cites W2070377532 @default.
• W2078585966 cites W2070745109 @default.
• W2078585966 cites W2071804879 @default.
• W2078585966 cites W2088895425 @default.
• W2078585966 cites W2098958062 @default.
• W2078585966 cites W2100837269 @default.
• W2078585966 cites W2101186431 @default.
• W2078585966 cites W2108665041 @default.
• W2078585966 cites W2115017173 @default.
• W2078585966 cites W2117349394 @default.
• W2078585966 cites W2126412451 @default.
• W2078585966 cites W2126823382 @default.
• W2078585966 cites W2129471240 @default.
• W2078585966 cites W2132547000 @default.
• W2078585966 cites W2164336743 @default.
• W2078585966 cites W2165127373 @default.
• W2078585966 cites W2167013890 @default.
• W2078585966 doi "https://doi.org/10.1152/ajpcell.00042.2007" @default.
• W2078585966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17977947" @default.
• W2078585966 hasPublicationYear "2008" @default.
• W2078585966 type Work @default.
• W2078585966 sameAs 2078585966 @default.
• W2078585966 citedByCount "11" @default.
• W2078585966 countsByYear W20785859662013 @default.
• W2078585966 countsByYear W20785859662014 @default.
• W2078585966 crossrefType "journal-article" @default.
• W2078585966 hasAuthorship W2078585966A5000241718 @default.
• W2078585966 hasAuthorship W2078585966A5006269031 @default.
• W2078585966 hasAuthorship W2078585966A5010366988 @default.
• W2078585966 hasAuthorship W2078585966A5011493936 @default.
• W2078585966 hasAuthorship W2078585966A5026164472 @default.
• W2078585966 hasAuthorship W2078585966A5044742086 @default.
• W2078585966 hasAuthorship W2078585966A5058670897 @default.
• W2078585966 hasAuthorship W2078585966A5060222207 @default.
• W2078585966 hasAuthorship W2078585966A5070818874 @default.
• W2078585966 hasAuthorship W2078585966A5083251487 @default.
• W2078585966 hasAuthorship W2078585966A5084108232 @default.
• W2078585966 hasAuthorship W2078585966A5084519057 @default.
• W2078585966 hasAuthorship W2078585966A5091187358 @default.
• W2078585966 hasConcept C126322002 @default.
• W2078585966 hasConcept C134018914 @default.
• W2078585966 hasConcept C185592680 @default.
• W2078585966 hasConcept C24998067 @default.
• W2078585966 hasConcept C2775910092 @default.
• W2078585966 hasConcept C2776989580 @default.
• W2078585966 hasConcept C2777622882 @default.
• W2078585966 hasConcept C2778326061 @default.
• W2078585966 hasConcept C2778483698 @default.
• W2078585966 hasConcept C2779936771 @default.
• W2078585966 hasConcept C2780773033 @default.
• W2078585966 hasConcept C2908688039 @default.
• W2078585966 hasConcept C29688787 @default.
• W2078585966 hasConcept C519063684 @default.
• W2078585966 hasConcept C519581460 @default.
• W2078585966 hasConcept C543025807 @default.
• W2078585966 hasConcept C55493867 @default.
• W2078585966 hasConcept C71924100 @default.
• W2078585966 hasConceptScore W2078585966C126322002 @default.
• W2078585966 hasConceptScore W2078585966C134018914 @default.
• W2078585966 hasConceptScore W2078585966C185592680 @default.
• W2078585966 hasConceptScore W2078585966C24998067 @default.
• W2078585966 hasConceptScore W2078585966C2775910092 @default.

• next