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- W2078590003 abstract "Gene expression and its regulation was studied in the rat tapeworm, Hymenolepis diminuta, during strobilization. RNAs extracted from the different developmental stages of the parasite were translated in vitro in a rabbit reticulocyte lysate system. Two-dimensional patterns of the translational products were compared with the 2-dimensional patterns obtained by metabolic labelling with [35S]methionine. The results indicated a post-transcriptional regulation of gene expression during strobilization in this parasite. Gene expression and its regulation was also studied in H. diminuta obtained from ‘non-permissive’ hosts (mice) and immune suppressed mice and compared with the parasites of the same age obtained from ‘permissive’ rat hosts. The 2-dimensional patterns of the in vitro translation products, obtained by translating the RNA of different groups of parasites, were compared with the patterns of gene products obtained from parasites using [35S]methionine metabolic labelling. The results indicated a massive post-transcriptional regulation of gene expression, the latter inhibited in parasites obtained from normal mice, but not in immune suppressed mice." @default.
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- W2078590003 date "1987-08-01" @default.
- W2078590003 modified "2023-09-26" @default.
- W2078590003 title "Developmental and immune regulation of gene expression in Hymenolepis diminuta" @default.
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- W2078590003 doi "https://doi.org/10.1016/0166-6851(87)90014-4" @default.
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