FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078592321> ?p ?o ?g. }

• W2078592321 endingPage "1069" @default.
• W2078592321 startingPage "1060" @default.
• W2078592321 abstract "Aerolysin, a secreted bacterial toxin from Aeromonas hydrophila, binds to glycosylphosphatidylinositol (GPI)-anchored protein and kills the cells by forming pores. Both GPI and N-glycan moieties of GPI-anchored proteins are involved in efficient binding of aerolysin. We isolated various Chinese hamster ovary (CHO) mutant cells resistant to aerolysin. Among them, CHOPA41.3 mutant cells showed several-fold decreased expression of GPI-anchored proteins. After transfection of N-acetylglucosamine transferase I (GnT1) cDNA, aerolysin was efficiently bound to the cells, indicating that the resistance against aerolysin in this cells was mainly ascribed to the defect of N-glycan maturation. CHOPA41.3 cells also accumulated GPI intermediates lacking ethanolamine phosphate modification on the first mannose. After stable transfection of PIG-N cDNA encoding GPI-ethanolamine phosphate transferase1, a profile of accumulated GPI intermediates became similar to that of GPI transamidase mutant cells. It indicated, therefore, that CHOPA41.3 cells are defective in GnT1, ethanolamine phosphate modification of the first mannose, and attachment of GPI to proteins. The GPI accumulation in CHOPA41.3 cells carrying PIG-N cDNA was not normalized after transfection with cDNAs of all known components in GPI transamidase complex. Microsomes from CHOPA41.3 cells had normal GPI transamidase activity. Taken together, there is an unknown gene required for efficient attachment of GPI to proteins." @default.
• W2078592321 created "2016-06-24" @default.
• W2078592321 creator A5012838498 @default.
• W2078592321 creator A5051611788 @default.
• W2078592321 creator A5064751736 @default.
• W2078592321 creator A5072623856 @default.
• W2078592321 creator A5079004842 @default.
• W2078592321 creator A5088528604 @default.
• W2078592321 creator A5091406841 @default.
• W2078592321 date "2005-10-01" @default.
• W2078592321 modified "2023-09-26" @default.
• W2078592321 title "New mutant Chinese hamster ovary cell representing an unknown gene for attachment of glycosylphosphatidylinositol to proteins" @default.
• W2078592321 cites W1492544808 @default.
• W2078592321 cites W1503075447 @default.
• W2078592321 cites W1524475863 @default.
• W2078592321 cites W1535479800 @default.
• W2078592321 cites W1542354017 @default.
• W2078592321 cites W1562203178 @default.
• W2078592321 cites W1891864413 @default.
• W2078592321 cites W1968271109 @default.
• W2078592321 cites W1992234272 @default.
• W2078592321 cites W1993505002 @default.
• W2078592321 cites W1995666217 @default.
• W2078592321 cites W2001387533 @default.
• W2078592321 cites W2003322429 @default.
• W2078592321 cites W2013177319 @default.
• W2078592321 cites W2022408153 @default.
• W2078592321 cites W2023359733 @default.
• W2078592321 cites W2042540642 @default.
• W2078592321 cites W2051722675 @default.
• W2078592321 cites W2053396821 @default.
• W2078592321 cites W2055071063 @default.
• W2078592321 cites W2061070956 @default.
• W2078592321 cites W2061254873 @default.
• W2078592321 cites W2065344369 @default.
• W2078592321 cites W2070447989 @default.
• W2078592321 cites W2072633195 @default.
• W2078592321 cites W2080323034 @default.
• W2078592321 cites W2080429285 @default.
• W2078592321 cites W2081978633 @default.
• W2078592321 cites W2082557203 @default.
• W2078592321 cites W2086560533 @default.
• W2078592321 cites W2099694432 @default.
• W2078592321 cites W2107175187 @default.
• W2078592321 cites W2114283841 @default.
• W2078592321 cites W2118817852 @default.
• W2078592321 cites W2122116013 @default.
• W2078592321 cites W2124676316 @default.
• W2078592321 cites W2124818234 @default.
• W2078592321 cites W2129597030 @default.
• W2078592321 cites W2138340768 @default.
• W2078592321 cites W2138447045 @default.
• W2078592321 cites W2139408018 @default.
• W2078592321 cites W2144077307 @default.
• W2078592321 cites W2144528434 @default.
• W2078592321 cites W2146488895 @default.
• W2078592321 cites W2147611281 @default.
• W2078592321 cites W2156852013 @default.
• W2078592321 cites W2158957854 @default.
• W2078592321 cites W2161998178 @default.
• W2078592321 cites W4230864451 @default.
• W2078592321 doi "https://doi.org/10.1016/j.bbrc.2005.07.177" @default.
• W2078592321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16102723" @default.
• W2078592321 hasPublicationYear "2005" @default.
• W2078592321 type Work @default.
• W2078592321 sameAs 2078592321 @default.
• W2078592321 citedByCount "6" @default.
• W2078592321 countsByYear W20785923212012 @default.
• W2078592321 countsByYear W20785923212014 @default.
• W2078592321 countsByYear W20785923212015 @default.
• W2078592321 crossrefType "journal-article" @default.
• W2078592321 hasAuthorship W2078592321A5012838498 @default.
• W2078592321 hasAuthorship W2078592321A5051611788 @default.
• W2078592321 hasAuthorship W2078592321A5064751736 @default.
• W2078592321 hasAuthorship W2078592321A5072623856 @default.
• W2078592321 hasAuthorship W2078592321A5079004842 @default.
• W2078592321 hasAuthorship W2078592321A5088528604 @default.
• W2078592321 hasAuthorship W2078592321A5091406841 @default.
• W2078592321 hasConcept C104317684 @default.
• W2078592321 hasConcept C108625454 @default.
• W2078592321 hasConcept C143065580 @default.
• W2078592321 hasConcept C153911025 @default.
• W2078592321 hasConcept C170493617 @default.
• W2078592321 hasConcept C174319367 @default.
• W2078592321 hasConcept C175656101 @default.
• W2078592321 hasConcept C187882448 @default.
• W2078592321 hasConcept C206212055 @default.
• W2078592321 hasConcept C2775887612 @default.
• W2078592321 hasConcept C54009773 @default.
• W2078592321 hasConcept C55493867 @default.
• W2078592321 hasConcept C60987743 @default.
• W2078592321 hasConcept C86803240 @default.
• W2078592321 hasConceptScore W2078592321C104317684 @default.
• W2078592321 hasConceptScore W2078592321C108625454 @default.
• W2078592321 hasConceptScore W2078592321C143065580 @default.
• W2078592321 hasConceptScore W2078592321C153911025 @default.
• W2078592321 hasConceptScore W2078592321C170493617 @default.
• W2078592321 hasConceptScore W2078592321C174319367 @default.

• next