FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078595203> ?p ?o ?g. }

• W2078595203 endingPage "320" @default.
• W2078595203 startingPage "315" @default.
• W2078595203 abstract "The antihypertensive mechanisms of single and combined therapy with a beta-adrenergic antagonist (propranolol) and a vasodilator (hydralazine) were investigated in 9 patients with moderately severe hypertension, who were receiving maintenance diuretic (hydrochlorothiazide) treatment. Hemodynamic and neuroendocrine responses were determined at rest and during lower body negative pressure, and dynamic and static exercise stress after the chronic administration of propranolol and hydralazine, given alone or in combination. All 3 drug regimens, each administered for at least 10 weeks, reduced blood pressure (p less than 0.05) compared with diuretic-only therapy in patients at rest, in both the supine and standing position, and during lower body negative pressure and dynamic exercise. There was a significant additive antihypertensive effect when propranolol and hydralazine were combined. Only combination therapy effectively lowered pressure during static exercise. The regimens produced divergent effects on the supine cardiac output: a decrease with propranolol (p less than 0.05), no change with combination therapy and an increase with hydralazine (p less than 0.05). Both hydralazine and combination therapy significantly reduced supine total peripheral resistance (p less than 0.05), whereas propranolol produced no change. All 3 drug treatments significantly reduced total peripheral resistance during upright rest and dynamic exercise (p less than 0.05), without changing cardiac output or maximal exercise capacity. During exercise, cardiac output was maintained in patients treated with propranolol and in those treated with combined therapy by increases in stroke volume (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2078595203 created "2016-06-24" @default.
• W2078595203 creator A5021863838 @default.
• W2078595203 creator A5033054250 @default.
• W2078595203 creator A5034895031 @default.
• W2078595203 creator A5062085593 @default.
• W2078595203 creator A5071231920 @default.
• W2078595203 creator A5083422196 @default.
• W2078595203 date "1985-08-01" @default.
• W2078595203 modified "2023-09-23" @default.
• W2078595203 title "Single and combined therapy for systemic hypertension with propranolol, hydralazine and hydrochlorothiazide: Hemodynamic and neuroendocrine mechanisms of action" @default.
• W2078595203 cites W109319306 @default.
• W2078595203 cites W1547854467 @default.
• W2078595203 cites W180625220 @default.
• W2078595203 cites W1972651622 @default.
• W2078595203 cites W1973443763 @default.
• W2078595203 cites W1981151391 @default.
• W2078595203 cites W1993050729 @default.
• W2078595203 cites W1997388963 @default.
• W2078595203 cites W2024722093 @default.
• W2078595203 cites W2024885103 @default.
• W2078595203 cites W2027197771 @default.
• W2078595203 cites W2029034815 @default.
• W2078595203 cites W2061265990 @default.
• W2078595203 cites W2062749232 @default.
• W2078595203 cites W2063246359 @default.
• W2078595203 cites W2068106147 @default.
• W2078595203 cites W2072241013 @default.
• W2078595203 cites W2081487004 @default.
• W2078595203 cites W2083304301 @default.
• W2078595203 cites W2113471494 @default.
• W2078595203 cites W2288851995 @default.
• W2078595203 cites W2311561033 @default.
• W2078595203 cites W2336731445 @default.
• W2078595203 cites W2337755553 @default.
• W2078595203 cites W2339719629 @default.
• W2078595203 cites W2418214284 @default.
• W2078595203 cites W2461703662 @default.
• W2078595203 cites W262393329 @default.
• W2078595203 cites W3205848284 @default.
• W2078595203 cites W600728777 @default.
• W2078595203 cites W75249207 @default.
• W2078595203 doi "https://doi.org/10.1016/0002-9149(85)90856-2" @default.
• W2078595203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4025172" @default.
• W2078595203 hasPublicationYear "1985" @default.
• W2078595203 type Work @default.
• W2078595203 sameAs 2078595203 @default.
• W2078595203 citedByCount "3" @default.
• W2078595203 countsByYear W20785952032013 @default.
• W2078595203 countsByYear W20785952032015 @default.
• W2078595203 crossrefType "journal-article" @default.
• W2078595203 hasAuthorship W2078595203A5021863838 @default.
• W2078595203 hasAuthorship W2078595203A5033054250 @default.
• W2078595203 hasAuthorship W2078595203A5034895031 @default.
• W2078595203 hasAuthorship W2078595203A5062085593 @default.
• W2078595203 hasAuthorship W2078595203A5071231920 @default.
• W2078595203 hasAuthorship W2078595203A5083422196 @default.
• W2078595203 hasConcept C125567185 @default.
• W2078595203 hasConcept C126322002 @default.
• W2078595203 hasConcept C139940330 @default.
• W2078595203 hasConcept C164705383 @default.
• W2078595203 hasConcept C178853913 @default.
• W2078595203 hasConcept C2777953023 @default.
• W2078595203 hasConcept C2778151854 @default.
• W2078595203 hasConcept C2779918671 @default.
• W2078595203 hasConcept C2780361556 @default.
• W2078595203 hasConcept C2780521442 @default.
• W2078595203 hasConcept C42219234 @default.
• W2078595203 hasConcept C71924100 @default.
• W2078595203 hasConcept C80461066 @default.
• W2078595203 hasConcept C84393581 @default.
• W2078595203 hasConceptScore W2078595203C125567185 @default.
• W2078595203 hasConceptScore W2078595203C126322002 @default.
• W2078595203 hasConceptScore W2078595203C139940330 @default.
• W2078595203 hasConceptScore W2078595203C164705383 @default.
• W2078595203 hasConceptScore W2078595203C178853913 @default.
• W2078595203 hasConceptScore W2078595203C2777953023 @default.
• W2078595203 hasConceptScore W2078595203C2778151854 @default.
• W2078595203 hasConceptScore W2078595203C2779918671 @default.
• W2078595203 hasConceptScore W2078595203C2780361556 @default.
• W2078595203 hasConceptScore W2078595203C2780521442 @default.
• W2078595203 hasConceptScore W2078595203C42219234 @default.
• W2078595203 hasConceptScore W2078595203C71924100 @default.
• W2078595203 hasConceptScore W2078595203C80461066 @default.
• W2078595203 hasConceptScore W2078595203C84393581 @default.
• W2078595203 hasIssue "4" @default.
• W2078595203 hasLocation W20785952031 @default.
• W2078595203 hasLocation W20785952032 @default.
• W2078595203 hasOpenAccess W2078595203 @default.
• W2078595203 hasPrimaryLocation W20785952031 @default.
• W2078595203 hasRelatedWork W1495099895 @default.
• W2078595203 hasRelatedWork W2024580737 @default.
• W2078595203 hasRelatedWork W2028032510 @default.
• W2078595203 hasRelatedWork W2078595203 @default.
• W2078595203 hasRelatedWork W2314165071 @default.
• W2078595203 hasRelatedWork W231430250 @default.
• W2078595203 hasRelatedWork W2412222853 @default.
• W2078595203 hasRelatedWork W2416179747 @default.

• next