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- W2078595712 abstract "It has been shown that inhibition of GTPase activating protein of Arf1 with a small molecule (QS11) results in synergistic activation Wnt signaling, however, it was not proven if Arf1 is a bona fide regulator of Wnt/beta-catenin signaling. Transient expression of Arf1 synergistically enhanced Wnt3a induced reporter luciferase activity and depletion of Arf1 inhibited the Wnt mediated cytoplasmic beta-catenin increase. Interestingly, the level of active form of Arf1 (Arf1-GTP) was transiently, in between 15 and 30 min, enhanced upon treatment of Wnt3a conditioned media and this induction was eliminated via blocking of interaction between Wnt and Fzd or knock-down of Fzds, Dvls or LRP6. Knock-down of ARNO family, the Arf-GEF, attenuated Wnt mediated Arf1 activation. Depletion of Arf1 led to blocking of Wnt mediated formation of Ptdlns (4,5)P2 (phosphatidylinositol 4,5 bisphosphate) and LRP6 phosphorylation, which are required for the initiation of Wnt signaling. Overall our data strongly suggest that transient activation of Arf1 is necessary for the initiation of Wnt/beta-catenin signaling and Arf1 is a genuine regulator. Supported by the Korea Research Foundation (Grant C00339) and Brain Korea 21 program." @default.
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- W2078595712 date "2010-11-01" @default.
- W2078595712 modified "2023-10-18" @default.
- W2078595712 title "P134. ADP-ribosylation factor1 is a bona fide regulator of Wnt/beta-catenin signaling" @default.
- W2078595712 doi "https://doi.org/10.1016/j.diff.2010.09.140" @default.
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