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- W2078595733 abstract "Purpose To investigate changes in microRNA (miR) expression in ocular adnexal extranodal marginal zone lymphoma (EMZL) and diffuse large B-cell lymphoma (DLBCL), and to perform a pathway analysis of differentially expressed miRs.Methods Global miR expression profiling was performed using miRCURYTM LNA miR-arrays, v. 11.0, (Exiqon) on formalin-fixed paraffin-embedded tissue from 18 ocular adnexal EMZLs and 25 DLBCLs. The result of microarray was confirmed using quantitative real time (RT)-PCR. Predicted and validated targets of the significantly differentially expressed miRs were obtained from MiR-walk. Transcription factor (TF)-miR interactions were obtained from the TransmiR database.Results The microarray results revealed two up-regulated and 41 down-regulated miRs in the DLBCLs compared to the EMZLs. Further, the differentially expressed miRs separated EMZLs and DLBCLs into two distinct entities using a supervised clustering analysis. These findings were confirmed by quantitative RT-PCR. Five of the down-regulated miRs (let-7g, miR-26a, miR-29a, miR-29c and miR-221) were identified to be regulated negatively by MYC. A small set of miRs (let-7g, miR-199a-5, miR-26a, miR-27a* and miR-342-3p) that regulate NFKB1 were all down-regulated in the DLBCLs compared to the EMZL samples. Further, the NFKB1 regulated miRs (miR-29a/b/c and miR-125b) were down-regulated significantly in the DLBCLs compared with the EMZLs (log2 fold-changes: miR-29a/b/c < -1.9 and -1.1 for miR-125b).Conclusion We demonstrated that fundamental differences in miR expression exist between ocular adnexal EMZLs and DLBCLs, mainly due to differences in MYC and NF-kB regulatory pathways." @default.
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- W2078595733 date "2012-08-06" @default.
- W2078595733 modified "2023-09-27" @default.
- W2078595733 title "MicroRNA profiling in ocular adnexal extranodal marginal zone lymphoma and diffuse large B-cell lymphoma" @default.
- W2078595733 doi "https://doi.org/10.1111/j.1755-3768.2012.4666.x" @default.
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