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- W2078595938 abstract "A novel optical heterodyne surface-plasmon resonance (SPR) biosensor with a Zeeman laser is proposed. Two surface plasma waves are excited by two correlated p -polarized waves in a SPR device of the Kretschmann configuration. Two reflected p waves are optically heterodyned such that the magnitude of the heterodyned signal is proportional to the multiplication of two attenuated reflected p waves. Then the detection sensitivity and the dynamic range based on this amplitude-sensitive method are enhanced. In the experiment, the kinetics between mouse immunoglobulin G (IgG) and rabbit antimouse IgG is obtained from sensograms of various concentrations of antimouse IgG. A detection sensitivity of 0.2 nM was achieved. In addition, a concentration of 5 ng/Fml of protein G interacting with mouse IgG was measured successfully." @default.
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- W2078595938 date "2003-08-01" @default.
- W2078595938 modified "2023-09-25" @default.
- W2078595938 title "Optical heterodyne surface-plasmon resonance biosensor" @default.
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- W2078595938 doi "https://doi.org/10.1364/ol.28.001329" @default.
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