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- W2078596153 abstract "Three mouse cyclin-like (CYL) genes were lsolated, two of which are regulated by colony-stimulating factor 1 (CSF-1) during the G1 phase of the macrophage cell cycle. CSF-1 deprivation during G1 leads to rapid degradation of CYL proteins (p36CYL) and correlates with fallure to initiate DNA synthesis. However, after entering S phase, macrophages no longer require CSF-1 and can complete cell division without expressing CYL genes. During G1, p36CYL is phosphorylated and associates with a polypeptide antigenically related to p34cdc2. The timing of p36CYL expression, its rapid turnover in the absence of CSF-1, and its phosphorylation and transient binding to a cdc2-related polypeptide suggest that CYL genes may function during S phase commitment." @default.
- W2078596153 created "2016-06-24" @default.
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- W2078596153 creator A5027928253 @default.
- W2078596153 creator A5070772930 @default.
- W2078596153 creator A5081337406 @default.
- W2078596153 date "1991-05-01" @default.
- W2078596153 modified "2023-10-18" @default.
- W2078596153 title "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle" @default.
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- W2078596153 doi "https://doi.org/10.1016/0092-8674(91)90101-4" @default.
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