FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078596809> ?p ?o ?g. }

• W2078596809 endingPage "109" @default.
• W2078596809 startingPage "100" @default.
• W2078596809 abstract "Acute lymphoblastic leukemia (ALL) is the most common form of pediatric cancer. Although exposure to environmental agents appears to predispose individuals to this disease, little attention has been paid to the role of genetic susceptibility to environmental exposures in the etiology of childhood ALL. The enzymes GSTM1, GSTT1, GSTP1, CYP1A1, and CYP2E1 are involved in the bioactivation and detoxification of a variety of xenobiotics present in food, organic solvents, tobacco smoke, drugs, alcoholic drinks, pesticides, and environmental pollutants. Polymorphisms in the genes coding for these enzymes have been associated with increased susceptibility to different cancers, including hematologic malignancies. To investigate whether these polymorphisms represent risk-modifying factors for childhood ALL, a study was conducted involving 113 Brazilian patients of childhood ALL and 221 controls with similar ethnic backgrounds. The data revealed that carriers of the rare GSTP1 Val allele were at higher risk of ALL (odds ratio [OR] = 2.7; 95% confidence interval [CI] = 1.1-6.8; P = 0.04). No difference was found in the prevalence of the GSTM1 and GSTT1 null genotypes between ALL patients and the controls, and no association was found between CYP1A1*2 and CYP2E1*3 variants and ALL. However, when the mutant CYP1A1 and CYP2E1 alleles were considered together with the GSTM1 and GSTP1 risk-elevating genotypes, the risk of ALL was increased further (OR = 10.3; 95% CI = 1.0-111.8; P = 0.05), suggesting a combined effect. These results imply that genetic variants of xenobiotic metabolizing genes influence the risk of developing childhood ALL." @default.
• W2078596809 created "2016-06-24" @default.
• W2078596809 creator A5020583774 @default.
• W2078596809 creator A5028961295 @default.
• W2078596809 creator A5057375531 @default.
• W2078596809 creator A5089350518 @default.
• W2078596809 date "2004-01-01" @default.
• W2078596809 modified "2023-10-14" @default.
• W2078596809 title "Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia" @default.
• W2078596809 cites W113982714 @default.
• W2078596809 cites W152275921 @default.
• W2078596809 cites W1578826674 @default.
• W2078596809 cites W1750764013 @default.
• W2078596809 cites W1848867726 @default.
• W2078596809 cites W1914476337 @default.
• W2078596809 cites W1961883110 @default.
• W2078596809 cites W1964828966 @default.
• W2078596809 cites W1966927617 @default.
• W2078596809 cites W1968246855 @default.
• W2078596809 cites W1974372375 @default.
• W2078596809 cites W1984158775 @default.
• W2078596809 cites W1984183164 @default.
• W2078596809 cites W1984526747 @default.
• W2078596809 cites W1985206870 @default.
• W2078596809 cites W1986029619 @default.
• W2078596809 cites W1988708581 @default.
• W2078596809 cites W1989108484 @default.
• W2078596809 cites W1991265015 @default.
• W2078596809 cites W1999463250 @default.
• W2078596809 cites W2002240712 @default.
• W2078596809 cites W2004500862 @default.
• W2078596809 cites W2004947323 @default.
• W2078596809 cites W2005789639 @default.
• W2078596809 cites W2007263773 @default.
• W2078596809 cites W2010347552 @default.
• W2078596809 cites W2011412712 @default.
• W2078596809 cites W2011783391 @default.
• W2078596809 cites W2012335460 @default.
• W2078596809 cites W2012810505 @default.
• W2078596809 cites W2019710193 @default.
• W2078596809 cites W2021185774 @default.
• W2078596809 cites W2021223798 @default.
• W2078596809 cites W2023139203 @default.
• W2078596809 cites W2026550655 @default.
• W2078596809 cites W2052447033 @default.
• W2078596809 cites W2059410642 @default.
• W2078596809 cites W2063801983 @default.
• W2078596809 cites W2063919832 @default.
• W2078596809 cites W2069296209 @default.
• W2078596809 cites W2072059188 @default.
• W2078596809 cites W2076426515 @default.
• W2078596809 cites W2079731458 @default.
• W2078596809 cites W2080758266 @default.
• W2078596809 cites W2080790710 @default.
• W2078596809 cites W2088524561 @default.
• W2078596809 cites W2090347206 @default.
• W2078596809 cites W2091705672 @default.
• W2078596809 cites W2093257129 @default.
• W2078596809 cites W2095634900 @default.
• W2078596809 cites W2101181611 @default.
• W2078596809 cites W2109157775 @default.
• W2078596809 cites W2110676557 @default.
• W2078596809 cites W2112710602 @default.
• W2078596809 cites W2114381434 @default.
• W2078596809 cites W2120928354 @default.
• W2078596809 cites W2126214326 @default.
• W2078596809 cites W2140597941 @default.
• W2078596809 cites W2149384322 @default.
• W2078596809 cites W2149853199 @default.
• W2078596809 cites W2158263952 @default.
• W2078596809 cites W2188965485 @default.
• W2078596809 cites W2242790540 @default.
• W2078596809 cites W2253470886 @default.
• W2078596809 cites W2320180277 @default.
• W2078596809 cites W2419440397 @default.
• W2078596809 cites W4248071518 @default.
• W2078596809 cites W4360893946 @default.
• W2078596809 cites W51523625 @default.
• W2078596809 doi "https://doi.org/10.1002/em.20003" @default.
• W2078596809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14991750" @default.
• W2078596809 hasPublicationYear "2004" @default.
• W2078596809 type Work @default.
• W2078596809 sameAs 2078596809 @default.
• W2078596809 citedByCount "84" @default.
• W2078596809 countsByYear W20785968092012 @default.
• W2078596809 countsByYear W20785968092013 @default.
• W2078596809 countsByYear W20785968092014 @default.
• W2078596809 countsByYear W20785968092015 @default.
• W2078596809 countsByYear W20785968092016 @default.
• W2078596809 countsByYear W20785968092017 @default.
• W2078596809 countsByYear W20785968092018 @default.
• W2078596809 countsByYear W20785968092019 @default.
• W2078596809 countsByYear W20785968092020 @default.
• W2078596809 countsByYear W20785968092021 @default.
• W2078596809 countsByYear W20785968092022 @default.
• W2078596809 crossrefType "journal-article" @default.
• W2078596809 hasAuthorship W2078596809A5020583774 @default.
• W2078596809 hasAuthorship W2078596809A5028961295 @default.

• next