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• W2078596949 abstract "No AccessJournal of UrologyInvestigative Urology1 Apr 2011Enforced Expression of METCAM/MUC18 Increases Tumorigenesis of Human Prostate Cancer LNCaP Cells in Nude Mice Guang-Jer Wu, Mei-Whey H. Wu, Changsheng Wang, and Yuan Liu Guang-Jer WuGuang-Jer Wu Department of Microbiology and Immunology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia More articles by this author , Mei-Whey H. WuMei-Whey H. Wu Department of Microbiology and Immunology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia More articles by this author , Changsheng WangChangsheng Wang Biostatistics Shared Core Resources of Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia More articles by this author , and Yuan LiuYuan Liu Biostatistics Shared Core Resources of Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.11.052AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Metastasis cell adhesion molecule/MUC18, a cell adhesion molecule in the Ig-like gene super family, is a key determinant in prostate cancer cell progression. However, the mechanisms by which human metastasis cell adhesion molecule/MUC18 stimulates progression are poorly understood. To investigate this and determine whether human metastasis cell adhesion molecule/MUC18 may act as a possible tumor progression gene, we studied the effect of its enforced expression on LNCaP cell tumorigenesis. Materials and Methods: We subcutaneously co-injected a metastasis cell adhesion molecule/MUC18 expressing LNCaP clone and control clones/cells with Matrigel™ into nude mice, observed tumor formation of these cells and measured tumors at different times. To understand the mechanisms we also determined the expression of several downstream key effectors of metastasis cell adhesion molecule/MUC18 in subcutaneous tumors and compared them to those in previously obtained orthotopic (prostatic) tumors. Results: Tumors derived from human metastasis cell adhesion molecule/MUC18 expressing LNCaP clones/cells appeared about 18 days earlier than the empty vector transfected clone/cells. Enforced expression of human metastasis cell adhesion molecule/MUC18 also increased tumor take 2-fold, tumorigenicity 10 to 12-fold and final tumor weight 5-fold. Enforced expression appeared to render the cells with increased levels of the proliferation indexes Ki67 and proliferating cell nuclear antigen, the survival index phospho-AKT, and the angiogenesis indexes vascular endothelial growth factor, vascular endothelial growth factor receptor 2 and CD31. However, it did not significantly render the cells with altered levels of various apoptosis indexes. Conclusions: Enforced expression of human metastasis cell adhesion molecule/MUC18 increases prostate tumorigenesis in vivo and may affect the process by increasing proliferation, up-regulating the AKT survival pathway, and augmenting the angiogenic ability of prostate cancer cells. References 1 : Cellular motility and prostate carcinoma metastases. Cancer Metastasis Rev1993; 12: 53. Google Scholar 2 : Molecular mediators of interactions with extracellular matrix components in metastasis and angiogenesis. Curr Opin Oncol1994; 6: 106. Google Scholar 3 : Molecular biology of prostate development and prostate cancer. Ann Med1998; 30: 357. Google Scholar 4 : The role of MUC18 in prostate carcinoma. In: . Edited by . New York: Elsevier Science/Academic Press2005: 347. chapt 3.7. Google Scholar 5 : MUC18, a marker of tumor progression in human melanoma. Proc Natl Acad Sci USA1989; 86: 9891. 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Volume 185Issue 4April 2011Page: 1504-1512 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Keywordsprostatic neoplasmscell adhesion moleculesmicedisease progressionnudeprostateAcknowledgmentsJonathan Geekai Chang, Chad Lee and Eugene L. Son provided technical support; Changsheng Wang performed preliminary statistical analyses; and Jonathan Wu critically read the manuscript.MetricsAuthor Information Guang-Jer Wu Department of Microbiology and Immunology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia More articles by this author Mei-Whey H. Wu Department of Microbiology and Immunology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia More articles by this author Changsheng Wang Biostatistics Shared Core Resources of Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia More articles by this author Yuan Liu Biostatistics Shared Core Resources of Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2078596949 title "Enforced Expression of METCAM/MUC18 Increases Tumorigenesis of Human Prostate Cancer LNCaP Cells in Nude Mice" @default.
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