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• W2078598081 abstract "1. The present study shows the effects of imipramine in a single dose (10 mg kg(-1), p.o.) or following repeated (14 days, twice a day) treatment on the level of mRNA coding for D2 dopamine receptors in the rat caudate putamen (CP). Repeated administration of imipramine resulted in the increase of the level of mRNA coding for D2 dopamine receptors. 2. Radioligand binding studies with the D2 receptor agonist, [3H]-N-0437, indicated, that following imipramine administration, the affinity of the agonist for the D2 dopamine receptor significantly increased, though without any alterations in the Bmax. 3. Pharmacological manipulations (by use of forskolin, GppNHp and quinpirole) of the cyclic AMP generating system, ex vivo following administration of imipramine indicated that an up-regulation of factors inhibiting cyclic GMP formation takes place. 4. Most probably it is the D2 dopamine receptor which undergoes functional up-regulation, resulting from the enhancement of its biosynthesis." @default.
• W2078598081 created "2016-06-24" @default.
• W2078598081 creator A5017091786 @default.
• W2078598081 creator A5089673359 @default.
• W2078598081 date "1998-03-01" @default.
• W2078598081 modified "2023-09-26" @default.
• W2078598081 title "The effect of prolonged treatment with imipramine on the biosynthesis and functional characteristics of D₂ dopamine receptors in the rat caudate putamen" @default.
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• W2078598081 doi "https://doi.org/10.1038/sj.bjp.0701681" @default.
• W2078598081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565237" @default.
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• W2078598081 hasPublicationYear "1998" @default.
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