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- W2078598128 abstract "[reaction: see text] Conformationally constrained side chain-bridged cyclic peptides were prepared using bis-carboxylic acid ring spacers. These macrocyles were designed to inhibit protein-protein interactions mediated by the third PDZ domain (PDZ3) of a mammalian neuronal protein, PSD-95. Isothermal titration calorimetry (ITC) experiments measured dissociation constants in the low micromolar range. For each compound, the change in entropy (TdeltaS) of binding either is comparable in magnitude to the enthalpy change (deltaH) or is the predominant driving force for association." @default.
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- W2078598128 date "2005-03-01" @default.
- W2078598128 modified "2023-09-25" @default.
- W2078598128 title "Bridged Peptide Macrocycles as Ligands for PDZ Domain Proteins" @default.
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- W2078598128 doi "https://doi.org/10.1021/ol0475966" @default.
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