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• W2078600372 abstract "Ocular enucleation produces significant morphological and physiological changes in central visual areas. However, our knowledge of the molecular events resulting from eye enucleation in visual brain areas remains elusive. We characterized here the transcription nuclear factor kappa-B (NF-κB) activation induced by ocular enucleation in the rat superior colliculus (SC). We also tested the effectiveness of the synthetic glucocorticoid dexamethasone in inhibiting its activation. Electrophoretic mobility shift assays to detect NF-κB indicated that this transcription factor is activated in the SC from 1 h to day 15 postlesion. The expression of p65 and p50 proteins in the nuclear extracts was also increased. Dexamethasone treatment was able to significantly inhibit NF-κB activation. These findings suggest that this transcriptional factor is importantly involved in the visual system short-term processes that ensue after retinal lesions in the adult brain." @default.
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• W2078600372 date "2012-07-01" @default.
• W2078600372 modified "2023-09-27" @default.
• W2078600372 title "Eye enucleation activates the transcription nuclear factor kappa-B in the rat superior colliculus" @default.
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• W2078600372 doi "https://doi.org/10.1016/j.neulet.2012.05.051" @default.
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