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- W2078603260 abstract "Intravenous dimethyl sulfoxide (DMSO) has been utilized as a treatment for a number of acute inflammatory conditions and for cerebral edema following trauma in experimental and clinical cases. 2,5,9, 11,12,15,16,18,20.2t.23,2s In humans, DMSO at 1 g/kg, has been found to be more effective than mannitol, urea, cortisone or barbiturates in treating severe head trauma. TM This treatment is often the most economical and effective way of treating brain edema in acute equine neurological diseases, z In the horse, recommended intravenous dosages range from 0.1 g/kg to 4 g/kg in varying concentrations of up to 40% DMSO. l'2'r'1s'21 While the most commonly used dose is 1 g/kg 1,2,19,~ the adverse effects of DMSO given too rapidly at any dose have not been well documented in horses. Adverse effects relative to DMSO have been reported in human beings and a number of animal species. 4,8 These include intravascular hemolysis, hemoglobinuria, hyperosmolality, and transient increase in respiratory rate. Clinical signs associated with near lethal doses in experimental animals were spontaneous motor activity, tremors, myasthenia," @default.
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- W2078603260 date "1992-07-01" @default.
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- W2078603260 title "Adverse effects of rapid intravenous DMSO administration in horses" @default.
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- W2078603260 doi "https://doi.org/10.1016/s0737-0806(06)81448-6" @default.
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