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• W2078603442 abstract "1. Acetylsalicylic acid (ASA; 400 mg/kg, i.p.) increased serotonin (5-HT) content in rat brain but did not modify the number or the affinity of 5-HT1A receptors in the pons and the cerebral cortex, whereas the number of cortical 5-HT2 receptors decreased significantly. 2. Pretreatment with parachlorophenylaline (100 mg/kg/day for 4 days) depleted 5-HT brain content but modified neither the serum levels of salicylates nor the 5-HT2 cortical receptor characteristics, and it abolished the antinociceptive effect of ASA, 400 mg/kg, in the first phase of the formalin test. 3. These data support the involvement of the central serotonergic system in the antinociceptive activity of ASA." @default.
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• W2078603442 date "1998-11-01" @default.
• W2078603442 modified "2023-09-23" @default.
• W2078603442 title "Effect of Acetylsalicylic Acid on Formalin Test and on Serotonin System in the Rat Brain" @default.
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• W2078603442 doi "https://doi.org/10.1016/s0306-3623(98)00108-6" @default.
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