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• W2078603463 startingPage "291" @default.
• W2078603463 abstract "An exposure to an electromagnetic field (EMF) has been shown to enhance the membrane permeability of endothelial cells. This study investigates the effect of EMF on the modulation of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) for delivering saquinavir (SQV) and azidothymidine (AZT). To assess the transport of SQV and AZT, an EMF and P-gp/MRP (transport protein) inhibitors were employed to stimulate confluent human brain-microvascular endothelial cells (HBMECs) with the regulation of human astrocytes. SQV at 40 μM and AZT at 300 μM were acceptable dosages for the viability of HBMECs. Under an EMF, verapamil showed a higher ability to elevate the permeation across the blood-brain barrier (BBB) than probenecid during treating with SQV. The reverse was true during treating with AZT. After an exposure to an EMF and administration of SQV and AZT, P-gp and MRP1 localized on the luminal side of HBMECs, exhibiting polar characteristics of the cell membranes. The synergetic effect of an EMF exposure and efflux protein inhibition can be promising in delivering antiretroviral drugs across the BBB." @default.
• W2078603463 created "2016-06-24" @default.
• W2078603463 creator A5063177635 @default.
• W2078603463 creator A5081994323 @default.
• W2078603463 date "2012-03-01" @default.
• W2078603463 modified "2023-10-16" @default.
• W2078603463 title "Modulation of efflux proteins by electromagnetic field for delivering azidothymidine and saquinavir into the brain." @default.
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• W2078603463 doi "https://doi.org/10.1016/j.colsurfb.2011.11.020" @default.
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• W2078603463 hasPublicationYear "2012" @default.
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