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- W2078603504 abstract "Upon intraventricular injection in mice, tetanus toxin is not more toxic than by the i.v. or s.c. route. The protective effect of antitoxin against toxin given into the gastrocnemius muscle was measured by the survival time of the animals and by the enrichment of 125I-tetanus toxin in the lumbar cord. Protection was slightly increased by intraventricular as compared with i.m. application of antitoxin. Neuraminidase given i.m. or intraventricularly, does not influence the toxicity of tetanus toxin given i.m. Neuraminidase given i.m. did not diminish the spinal enrichment of radio-active toxin. Local paralysis of the lower leg of rats with botulinum A toxin did not influence the ascent of labeled tetanus toxin from the injected area. In mice the ascent was even increased under such conditions, apparently due to the longer persistence of the tetanus toxin depot in the paralyzed leg. Ascent was inferred from spinal enrichment. Autoradiography of mouse brain following intraventricular injection of 125I-toxin shows the ependyma and pia mater to be a considerable but not insurmountable barrier. The immediate subependymal and subpial areas contain radioactivity. Some radioactivity enters more deeply, following the fibre tracts. Accumulation within neurones was not pronounced, in contrast to the toxin enrichment within spinal neurones in local or generalized tetanus. The results indicate that: (a) the barrier between cerebrospinal fluid and brain severely impedes the movement of tetanus toxin, and probably also of antitoxin; (b) the discrete enrichment of toxin in early local and in early generalized tetanus could be related to axonal transport; (c) a functionally intact nerve ending is not a prerequisite for the peripheral uptake of toxin." @default.
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- W2078603504 title "Pharmacokinetic and histoautoradiographic evidence for the intraaxonal movement of toxin in the pathogenesis of tetanus" @default.
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- W2078603504 doi "https://doi.org/10.1016/0041-0101(78)90189-7" @default.
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