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• W2078603823 startingPage "255" @default.
• W2078603823 abstract "Aims Cerebral amyloid angiopathy ( CAA ) is a key pathological hallmark of Alzheimer's disease ( AD ) characterized by accumulation of amyloid‐beta ( A β) protein in blood vessel walls. CAA impairs vessel functioning, affects blood brain barrier integrity and accelerates cognitive decline of AD patients. Unfortunately, mechanisms underlying A β deposition in the vessel wall remain largely unknown. F actor XIIIa ( FXIIIa ) is a blood‐derived transglutaminase crucial in blood coagulation by cross‐linking fibrin molecules. Evidence is mounting that blood‐derived factors are present in CAA and may play a role in protein deposition in the vessel wall. We therefore investigated whether FXIIIa is present in CAA and if FXIIIa cross‐link activity affects A β aggregation. Methods Using immunohistochemistry, we investigated the distribution of FXIIIa , its activator thrombin and in situ FXIIIa activity in CAA in post‐mortem AD tissue. We used surface plasmon resonance and Western blot analysis to study binding of FXIIIa to A β and the formation of FXIIIa ‐ A β complexes, respectively. In addition, we studied cytotoxicity of FXIIIa ‐ A β complexes to cerebrovascular cells. Results FXIIIa , thrombin and in situ FXIIIa activity colocalize with the A β deposition in CAA . Furthermore, FXIIIa binds to A β with a higher binding affinity for A β 1–42 compared with A β 1–40 . Moreover, highly stable FXIIIa ‐ A β complexes are formed independently of FXIIIa cross‐linking activity that protected cerebrovascular cells from A β‐induced toxicity in vitro. Conclusions Our data showed that FXIIIa colocalizes with A β in CAA and that FXIIIa forms unique protein complexes with A β that might play an important role in A β deposition and persistence in the vessel wall." @default.
• W2078603823 created "2016-06-24" @default.
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• W2078603823 date "2015-05-30" @default.
• W2078603823 modified "2023-09-27" @default.
• W2078603823 title "The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (Aβ) and colocalizes with deposited Aβ in cerebral amyloid angiopathy" @default.
• W2078603823 cites W1671478575 @default.
• W2078603823 cites W1702796904 @default.
• W2078603823 cites W1935472980 @default.
• W2078603823 cites W1963515616 @default.
• W2078603823 cites W1965813357 @default.
• W2078603823 cites W1967237003 @default.
• W2078603823 cites W1967455040 @default.
• W2078603823 cites W1967709584 @default.
• W2078603823 cites W1974407647 @default.
• W2078603823 cites W1976541189 @default.
• W2078603823 cites W1981253817 @default.
• W2078603823 cites W1983250908 @default.
• W2078603823 cites W1984334449 @default.
• W2078603823 cites W1985116046 @default.
• W2078603823 cites W1985292728 @default.
• W2078603823 cites W1992330057 @default.
• W2078603823 cites W1993105690 @default.
• W2078603823 cites W1996447834 @default.
• W2078603823 cites W2005939543 @default.
• W2078603823 cites W2006858320 @default.
• W2078603823 cites W2020240430 @default.
• W2078603823 cites W2020824841 @default.
• W2078603823 cites W2025774809 @default.
• W2078603823 cites W2026247913 @default.
• W2078603823 cites W2033458389 @default.
• W2078603823 cites W2034218432 @default.
• W2078603823 cites W2035134904 @default.
• W2078603823 cites W2036894466 @default.
• W2078603823 cites W2038298070 @default.
• W2078603823 cites W2039222951 @default.
• W2078603823 cites W2043263723 @default.
• W2078603823 cites W2047066026 @default.
• W2078603823 cites W2047243884 @default.
• W2078603823 cites W2049061598 @default.
• W2078603823 cites W2052011238 @default.
• W2078603823 cites W2057612717 @default.
• W2078603823 cites W2059893562 @default.
• W2078603823 cites W2060117322 @default.
• W2078603823 cites W2063236931 @default.
• W2078603823 cites W2066601928 @default.
• W2078603823 cites W2067403820 @default.
• W2078603823 cites W2070830966 @default.
• W2078603823 cites W2073028053 @default.
• W2078603823 cites W2073255828 @default.
• W2078603823 cites W2073301177 @default.
• W2078603823 cites W2073516240 @default.
• W2078603823 cites W2073566962 @default.
• W2078603823 cites W2073748140 @default.
• W2078603823 cites W2074532891 @default.
• W2078603823 cites W2074661552 @default.
• W2078603823 cites W2076520722 @default.
• W2078603823 cites W2081182167 @default.
• W2078603823 cites W2083708879 @default.
• W2078603823 cites W2084484659 @default.
• W2078603823 cites W2092305357 @default.
• W2078603823 cites W2097680048 @default.
• W2078603823 cites W2102711224 @default.
• W2078603823 cites W2103619607 @default.
• W2078603823 cites W2105503070 @default.
• W2078603823 cites W2111898865 @default.
• W2078603823 cites W2119109232 @default.
• W2078603823 cites W2119451788 @default.
• W2078603823 cites W2123283886 @default.
• W2078603823 cites W2131495383 @default.
• W2078603823 cites W2135705524 @default.
• W2078603823 cites W2143250732 @default.
• W2078603823 cites W2143461767 @default.
• W2078603823 cites W2146074502 @default.
• W2078603823 cites W2152723000 @default.
• W2078603823 cites W2153767421 @default.
• W2078603823 cites W2156725274 @default.
• W2078603823 cites W2157648440 @default.
• W2078603823 cites W2170126665 @default.
• W2078603823 cites W3152443858 @default.
• W2078603823 doi "https://doi.org/10.1111/nan.12244" @default.
• W2078603823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25871449" @default.
• W2078603823 hasPublicationYear "2015" @default.
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