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- W2078604791 abstract "<h2>Summary</h2> Shifts in electrostatic surface charge of membranes have recently been highlighted as a significant factor contributing to protein targeting to the plasma membrane and nascent phagosomes. Intracellular, vacuole-adapted pathogens may also regulate surface charge of their vacuoles to establish a replicative niche. Since <i>Salmonella enterica</i> serovar Typhimurium controls trafficking of the <i>Salmonella</i>-containing vacuole (SCV) and inhibits its fusion with lysosomes, we investigated the contribution of surface charge to this process. Using recently developed fluorescent biosensors, we show that the bacterial phosphoinositide phosphatase SopB controls membrane surface charge of nascent SCVs by reducing levels of negatively charged lipids phosphatidylinositol-4,5-bisphosphate and phosphatidylserine. This SopB activity results in dissociation of a number of host-cell endocytic trafficking proteins from this compartment and inhibits SCV-lysosome fusion. Moreover, inducible reduction of negative charge rescues Δ<i>sopB</i> bacteria-containing SCVs from fusion with lysosomes. These results reveal a membrane-charge-based mechanism used by <i>S</i>. Typhimurium to control SCV maturation." @default.
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- W2078604791 date "2010-06-01" @default.
- W2078604791 modified "2023-10-15" @default.
- W2078604791 title "The Phosphoinositide Phosphatase SopB Manipulates Membrane Surface Charge and Trafficking of the Salmonella-Containing Vacuole" @default.
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- W2078604791 doi "https://doi.org/10.1016/j.chom.2010.05.011" @default.
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