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- W2078605884 abstract "L. D. Foil, J. L. Frazier and B. R. Norment. Partial characterization of lethal and neuroactive components of the brown recluse spider (Loxosceles reclusa) venom. Toxicon17, 347–354, 1979.—Loxosceles reclusa venom was separated by Sephadex G-50 gel filtration into three 280 nm absorbing peaks, two of which contained components lethal to insects. The heavy molecular weight (mol. wt) protein found in peak 1 caused knockdown and mortality in Musca domestica 20–24 hr after injection. The low mol. wt (less than 10,000) polypeptide in peak 2 was heat stable at 90°C and caused knockdown within 30 min and mortality within four hr after injection. Both whole venom and peak 2 contained components which caused a dramatic increase in the amplitude and frequency of the endogenous activity of the ventral nerve cord of Periplaneta americana. The neuroactive factor stimulated this activity to 680-fold and with 5 min produced a block which was reversible by saline irrigation. Gel filtration elutions of the low mol. wt lethal factor and the neuroactive factor overlapped but did not coincide." @default.
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- W2078605884 date "1979-01-01" @default.
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- W2078605884 title "Partial characterization of lethal and neuroactive components of the brown recluse spider (Loxosceles reclusa) venom" @default.
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- W2078605884 doi "https://doi.org/10.1016/0041-0101(79)90262-9" @default.
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