FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078605959> ?p ?o ?g. }

• W2078605959 endingPage "214" @default.
• W2078605959 startingPage "200" @default.
• W2078605959 abstract "Dendritic cells (DC) are crucial components of the early events of HIV infection. Dendritic cells capture and internalize HIV at mucosal surfaces and efficiently transfer the virus to CD4 + T cells in trans through infectious synapses ( trans ‐infection pathway). Alternatively, HIV‐1 replicates in DC (R5‐HIV‐1) ( cis ‐infection pathway). Here, we analyzed HIV trafficking in DC during the trans ‐infection pathway as well as the cis ‐infection pathway. Confocal immunofluorescence microscopy demonstrated that after capture by DC, R5‐HIV‐1 and HIV‐1 pseudotyped with vesicular stomatitis virus protein G colocalized in a viral compartment enriched in tetraspanins including CD81, CD82 and CD9, although at different levels, indicating a role of the viral envelope in targeting to the tetraspanin‐rich compartment. Replication of R5‐HIV‐1 in DC ( cis ‐infection pathway) also led to the accumulation, in an envelope‐independent manner, of mature viral particles in a tetraspanin‐rich compartment. A fraction of the HIV‐1‐containing compartments appeared directly accessible from the cell surface. In sharp contrast with the trans ‐infection pathway, the δ‐subunit of the adaptor protein 3 (AP‐3) complex was enriched on the HIV‐1‐containing compartment during R5‐HIV‐1 replication in DC ( cis ‐infection pathway). Downregulation of AP‐3 δ‐adaptin reduced significantly viral particle release from HIV‐1‐infected DC. Together, these studies demonstrate a role for AP‐3 in HIV replication in a tetraspanin‐rich compartment in DC and contribute to the elucidation of the trafficking pathways required for DC–T cell transfer of HIV‐1 infection, a critical step during the early events of HIV infection." @default.
• W2078605959 created "2016-06-24" @default.
• W2078605959 creator A5003904331 @default.
• W2078605959 creator A5019884656 @default.
• W2078605959 creator A5040469370 @default.
• W2078605959 date "2007-11-22" @default.
• W2078605959 modified "2023-10-12" @default.
• W2078605959 title "HIV-1 Replication in Dendritic Cells Occurs Through a Tetraspanin-Containing Compartment Enriched in AP-3" @default.
• W2078605959 cites W108460990 @default.
• W2078605959 cites W1525792717 @default.
• W2078605959 cites W1532225053 @default.
• W2078605959 cites W1560080751 @default.
• W2078605959 cites W1661544713 @default.
• W2078605959 cites W1813266103 @default.
• W2078605959 cites W1858978092 @default.
• W2078605959 cites W1972254082 @default.
• W2078605959 cites W1973195284 @default.
• W2078605959 cites W1976860461 @default.
• W2078605959 cites W1978141733 @default.
• W2078605959 cites W1983834667 @default.
• W2078605959 cites W1985599438 @default.
• W2078605959 cites W1991586131 @default.
• W2078605959 cites W1993452562 @default.
• W2078605959 cites W1993700308 @default.
• W2078605959 cites W2003629451 @default.
• W2078605959 cites W2014970708 @default.
• W2078605959 cites W2020072455 @default.
• W2078605959 cites W2025346994 @default.
• W2078605959 cites W2029873308 @default.
• W2078605959 cites W2033464993 @default.
• W2078605959 cites W2040026254 @default.
• W2078605959 cites W2043409853 @default.
• W2078605959 cites W2053584325 @default.
• W2078605959 cites W2054564712 @default.
• W2078605959 cites W2055295979 @default.
• W2078605959 cites W2058169924 @default.
• W2078605959 cites W2074327384 @default.
• W2078605959 cites W2075847325 @default.
• W2078605959 cites W2079232939 @default.
• W2078605959 cites W2083303371 @default.
• W2078605959 cites W2083889661 @default.
• W2078605959 cites W2084460699 @default.
• W2078605959 cites W2096292882 @default.
• W2078605959 cites W2098485024 @default.
• W2078605959 cites W2099473567 @default.
• W2078605959 cites W2099491642 @default.
• W2078605959 cites W2101515920 @default.
• W2078605959 cites W2102437990 @default.
• W2078605959 cites W2107627347 @default.
• W2078605959 cites W2109832682 @default.
• W2078605959 cites W2112095081 @default.
• W2078605959 cites W2116301223 @default.
• W2078605959 cites W2117299062 @default.
• W2078605959 cites W2122717735 @default.
• W2078605959 cites W2124493183 @default.
• W2078605959 cites W2124504184 @default.
• W2078605959 cites W2127815795 @default.
• W2078605959 cites W2130075587 @default.
• W2078605959 cites W2130448025 @default.
• W2078605959 cites W2130578430 @default.
• W2078605959 cites W2131761283 @default.
• W2078605959 cites W2133396499 @default.
• W2078605959 cites W2134206256 @default.
• W2078605959 cites W2149317992 @default.
• W2078605959 cites W2155011421 @default.
• W2078605959 cites W2155464947 @default.
• W2078605959 cites W2159452612 @default.
• W2078605959 cites W2159507231 @default.
• W2078605959 cites W2164630010 @default.
• W2078605959 cites W2170379872 @default.
• W2078605959 cites W2171108507 @default.
• W2078605959 cites W4249167162 @default.
• W2078605959 cites W57241277 @default.
• W2078605959 doi "https://doi.org/10.1111/j.1600-0854.2007.00678.x" @default.
• W2078605959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18034776" @default.
• W2078605959 hasPublicationYear "2007" @default.
• W2078605959 type Work @default.
• W2078605959 sameAs 2078605959 @default.
• W2078605959 citedByCount "62" @default.
• W2078605959 countsByYear W20786059592012 @default.
• W2078605959 countsByYear W20786059592013 @default.
• W2078605959 countsByYear W20786059592014 @default.
• W2078605959 countsByYear W20786059592015 @default.
• W2078605959 countsByYear W20786059592016 @default.
• W2078605959 countsByYear W20786059592017 @default.
• W2078605959 countsByYear W20786059592018 @default.
• W2078605959 countsByYear W20786059592019 @default.
• W2078605959 countsByYear W20786059592020 @default.
• W2078605959 countsByYear W20786059592021 @default.
• W2078605959 countsByYear W20786059592022 @default.
• W2078605959 crossrefType "journal-article" @default.
• W2078605959 hasAuthorship W2078605959A5003904331 @default.
• W2078605959 hasAuthorship W2078605959A5019884656 @default.
• W2078605959 hasAuthorship W2078605959A5040469370 @default.
• W2078605959 hasBestOaLocation W20786059591 @default.
• W2078605959 hasConcept C111368507 @default.
• W2078605959 hasConcept C127313418 @default.
• W2078605959 hasConcept C140704245 @default.

• next