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- W2078608832 abstract "Following the peak of the action potential (AP) in a twitch fiber from frog, a very rapid repolarization occurs to an approximately constant plateau level (the “after potential”) ∼30 mV more positive than the resting potential (RP) lasting several msecs before returning to the RP (Adrian & Peachey 1973; J. Physiol. 235:103-131). In order to help understand how currents shape the AP with such fibers mounted in a double-Vaseline gap chamber, we developed a finite-difference model of a propagating AP for this preparation. The model includes time- and voltage-dependent gating of the Na and K currents based on the Hodgkin-Huxley (HH) models. The assumed properties of the Na, K, and leak conductances for the surface membrane are from Table 1B of the above reference. The specific conductances for these currents in the T-system were assumed to be the same as those for the surface. An access resistance for the T-system was adjusted to give an ∼1-ms delay between the surface AP and that in the T-system. The model results indicate that the “after potential” can be explained by Na current resulting from recovery from inactivation - a new explanation for the “after potential” to our knowledge. Modelled APs with a Ca-activated K current, IK(Ca), replacing the HH K current in the model are consistent with measured APs at different Ca contents (Lamboley et al., 2013; Biophys. J. 104(2):290a). The model supports a relatively straight-forward way for analyzing these results leading to our conclusion that IK(Ca) is the main determinant of the rapid repolarization phase of the AP. Consequently, IK(Ca) comprises a very important negative feedback mechanism for controlling Ca2+ release from the sarcoplasmic reticulum." @default.
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- W2078608832 date "2015-01-01" @default.
- W2078608832 modified "2023-09-26" @default.
- W2078608832 title "Model of a Propagating Action Potential (AP) in a Twitch Skeletal Muscle Fiber Mounted in a Double-Vaseline-Gap Chamber - Currents Involved in Shaping the AP" @default.
- W2078608832 doi "https://doi.org/10.1016/j.bpj.2014.11.1481" @default.
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