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- W2078612085 endingPage "1210" @default.
- W2078612085 startingPage "1195" @default.
- W2078612085 abstract "Proteomics is essential for deciphering how molecules interact as a system and for understanding the functions of cellular systems in human disease; however, the unique characteristics of the human proteome, which include a high dynamic range of protein expression and extreme complexity due to a plethora of PTMs and sequence variations, make such analyses challenging. An emerging top-down MS-based proteomics approach, which provides a bird's eye view of all proteoforms, has unique advantages for the assessment of PTMs and sequence variations. Recently, a number of studies have showcased the potential of top-down proteomics for the unraveling of disease mechanisms and discovery of new biomarkers. Nevertheless, the top-down approach still faces significant challenges in terms of protein solubility, separation, and the detection of large intact proteins, as well as underdeveloped data analysis tools. Consequently, new technological developments are urgently needed to advance the field of top-down proteomics. Herein, we intend to provide an overview of the recent applications of top-down proteomics in biomedical research. Moreover, we will outline the challenges and opportunities facing top-down proteomics strategies aimed at understanding and diagnosing human diseases." @default.
- W2078612085 created "2016-06-24" @default.
- W2078612085 creator A5070053244 @default.
- W2078612085 creator A5076108060 @default.
- W2078612085 date "2014-05-01" @default.
- W2078612085 modified "2023-10-17" @default.
- W2078612085 title "Top-down proteomics in health and disease: Challenges and opportunities" @default.
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