Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078616156> ?p ?o ?g. }
- W2078616156 endingPage "1247" @default.
- W2078616156 startingPage "1242" @default.
- W2078616156 abstract "To date, testing of various cytokines for the stimulation of blood cell production has not demonstrated a consistent effect on peripheral platelet levels. In this report, we provide evidence that human recombinant IL-6 increased platelet production in mice, as measured by both peripheral platelet levels and [75Se]selenomethionine (75SeM) incorporation into newly forming platelets. Peripheral white blood cell counts also were increased, but only to a modest extent, and hematocrit values were unchanged. A dose-response relationship between the amount of IL-6 administered and platelet count, 75SeM incorporation, and white blood cell count was demonstrated. Detectable megakaryocyte and granulocyte-macrophage colony-forming cells in mice that had received IL-6 also were increased in both bone marrow and spleen. These results demonstrate the ability of a purified, recombinant protein to stimulate platelet production in vivo." @default.
- W2078616156 created "2016-06-24" @default.
- W2078616156 creator A5070425276 @default.
- W2078616156 creator A5078086017 @default.
- W2078616156 creator A5081974137 @default.
- W2078616156 date "1990-04-01" @default.
- W2078616156 modified "2023-10-10" @default.
- W2078616156 title "Stimulation of thrombopoiesis in mice by human recombinant interleukin 6." @default.
- W2078616156 cites W145118746 @default.
- W2078616156 cites W1569205163 @default.
- W2078616156 cites W157721590 @default.
- W2078616156 cites W1599937274 @default.
- W2078616156 cites W1814728082 @default.
- W2078616156 cites W182367328 @default.
- W2078616156 cites W1825344511 @default.
- W2078616156 cites W190052799 @default.
- W2078616156 cites W193297649 @default.
- W2078616156 cites W1988375907 @default.
- W2078616156 cites W1989497089 @default.
- W2078616156 cites W1994400225 @default.
- W2078616156 cites W2004650098 @default.
- W2078616156 cites W2014716602 @default.
- W2078616156 cites W2037927666 @default.
- W2078616156 cites W2038013885 @default.
- W2078616156 cites W2054663403 @default.
- W2078616156 cites W2057637494 @default.
- W2078616156 cites W2071595697 @default.
- W2078616156 cites W2119125561 @default.
- W2078616156 cites W2138579291 @default.
- W2078616156 cites W2153667962 @default.
- W2078616156 cites W2241474374 @default.
- W2078616156 cites W2298584763 @default.
- W2078616156 cites W2315613377 @default.
- W2078616156 cites W2325596206 @default.
- W2078616156 cites W2395610004 @default.
- W2078616156 cites W2398503445 @default.
- W2078616156 cites W2399063565 @default.
- W2078616156 cites W2399659077 @default.
- W2078616156 cites W2404757706 @default.
- W2078616156 cites W2408857414 @default.
- W2078616156 cites W2409811290 @default.
- W2078616156 cites W2410446149 @default.
- W2078616156 cites W2410575126 @default.
- W2078616156 cites W2410992494 @default.
- W2078616156 cites W2411781498 @default.
- W2078616156 cites W2412706078 @default.
- W2078616156 cites W2413204414 @default.
- W2078616156 cites W2415105166 @default.
- W2078616156 cites W2416120876 @default.
- W2078616156 cites W2416678689 @default.
- W2078616156 cites W2418064775 @default.
- W2078616156 cites W2419191151 @default.
- W2078616156 cites W2460106530 @default.
- W2078616156 cites W317152220 @default.
- W2078616156 cites W343740181 @default.
- W2078616156 cites W50110503 @default.
- W2078616156 cites W83016261 @default.
- W2078616156 cites W1764005200 @default.
- W2078616156 doi "https://doi.org/10.1172/jci114559" @default.
- W2078616156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296558" @default.
- W2078616156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2318977" @default.
- W2078616156 hasPublicationYear "1990" @default.
- W2078616156 type Work @default.
- W2078616156 sameAs 2078616156 @default.
- W2078616156 citedByCount "137" @default.
- W2078616156 countsByYear W20786161562012 @default.
- W2078616156 countsByYear W20786161562013 @default.
- W2078616156 countsByYear W20786161562014 @default.
- W2078616156 countsByYear W20786161562015 @default.
- W2078616156 countsByYear W20786161562019 @default.
- W2078616156 countsByYear W20786161562020 @default.
- W2078616156 countsByYear W20786161562023 @default.
- W2078616156 crossrefType "journal-article" @default.
- W2078616156 hasAuthorship W2078616156A5070425276 @default.
- W2078616156 hasAuthorship W2078616156A5078086017 @default.
- W2078616156 hasAuthorship W2078616156A5081974137 @default.
- W2078616156 hasBestOaLocation W20786161561 @default.
- W2078616156 hasConcept C104317684 @default.
- W2078616156 hasConcept C109159458 @default.
- W2078616156 hasConcept C126322002 @default.
- W2078616156 hasConcept C134018914 @default.
- W2078616156 hasConcept C137061746 @default.
- W2078616156 hasConcept C202751555 @default.
- W2078616156 hasConcept C203014093 @default.
- W2078616156 hasConcept C24998067 @default.
- W2078616156 hasConcept C2776958478 @default.
- W2078616156 hasConcept C2777863708 @default.
- W2078616156 hasConcept C2778488018 @default.
- W2078616156 hasConcept C2779705218 @default.
- W2078616156 hasConcept C2779979121 @default.
- W2078616156 hasConcept C2780007613 @default.
- W2078616156 hasConcept C2780931953 @default.
- W2078616156 hasConcept C2780959883 @default.
- W2078616156 hasConcept C28328180 @default.
- W2078616156 hasConcept C40767141 @default.
- W2078616156 hasConcept C55493867 @default.
- W2078616156 hasConcept C71924100 @default.
- W2078616156 hasConcept C86803240 @default.