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• W2078616336 startingPage "2447" @default.
• W2078616336 abstract "Biocompatible and biodegradable hydroxyapatite nanoparticles with a hollow core and mesoporous shell structure (denoted as hmHANPs) are synthesized by an opposite ion core/shell strategy and applied to pH-responsive intracellular drug delivery systems (DDS). The synthesized hmHANPs have several advantages over solid hydroxyapatite nanoparticles (HANPs), where the hollow and mesoporous structure enhances drug-loading capacity, and the thin hydroxyapatite shell structure reduces burst release of drug and provides pH-responsive release. Doxorubicin (DOX), a therapeutic anticancer drug, was loaded in hmHANPs and HANPs for intracellular drug delivery systems (DDS). Compared to HANPs having a low drug-loading efficacy (17.9%), hmHANPs exhibited an excellent drug-loading efficacy (93.7%). In addition, the release amount of DOX from hmHANPs was 2.5-fold the amount from HANPs. Compared with free DOX, the anticancer efficacy of DOX-loaded hmHANPs was greatly enhanced, as evidenced by the results of MTT assays and confocal laser scanning microscopy using breast cancer cells (BT-20). The synthesized hmHANPs show great potential as drug nanovehicles with high biocompatibility, enhanced drug loading, and pH-responsive features for future intracellular DDS." @default.
• W2078616336 created "2016-06-24" @default.
• W2078616336 creator A5040684696 @default.
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• W2078616336 date "2013-01-01" @default.
• W2078616336 modified "2023-10-01" @default.
• W2078616336 title "Hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) with enhanced drug loading and pH-responsive release properties for intracellular drug delivery" @default.
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• W2078616336 doi "https://doi.org/10.1039/c3tb20365d" @default.
• W2078616336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32261043" @default.
• W2078616336 hasPublicationYear "2013" @default.
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