FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078621572> ?p ?o ?g. }

• W2078621572 endingPage "130" @default.
• W2078621572 startingPage "122" @default.
• W2078621572 abstract "Anticardiolipin (aCL) and anti-beta2-glycoprotein I(antiβ2GPI) antibodies have been shown in animal models as not cross-reacting antibody populations. This observation prompted us to prove if anti-β2GPI exist in human sera by using a reliable method and then to investigate if these are independent from aCl antibodies. We have developed a new ELISA for the detection of anti-β2GPI antibodies employing the coating of the protein in carbonate buffer to irradiated microtitre plates and the filtration of serum samples, that makes irrelevant the binding to the uncoated wells. IgG F(ab) 2 fragments from IgG positive sera were shown bind β2GPI, providing that the binding was a specific antibody binding, mediated by the antigen binding site of the antibody molecule; moreover the antibodies were not able to differentiate native and delipidated β2GPI coated plates, making a possible role of a phospholipid contaminant unlikely. On the other hand, the phosphorus content of native as well as delipitated β2GPI was undetectable. IgG, but not IgM, anti-β2GPI antibodies were classically inhibited by the addition of soluble β2GPI, while cardiolipin liposomes appear to modify the reaction in a completely different way, possibly by the described interaction between cardiolipin and β2GPI. The application of the new ELISA to the study of patients has shown that: (1) the presence of anti-β2GPI is statistically associated with the presence of aCL antibodies (P < 0.0001), (2) anti-β2GPI antibodies are related to the classical features of antiphospholipid syndrome (thrombosis: P < 0.001; fetal loss: P < 0.001) while, in this series of patients, aCl antibodies are not (thrombosis: P < 0.126; fetal loss: P < 0.061)." @default.
• W2078621572 created "2016-06-24" @default.
• W2078621572 creator A5002803770 @default.
• W2078621572 creator A5005168112 @default.
• W2078621572 creator A5012925118 @default.
• W2078621572 creator A5030466896 @default.
• W2078621572 creator A5074400852 @default.
• W2078621572 creator A5079447134 @default.
• W2078621572 creator A5079468607 @default.
• W2078621572 creator A5087114501 @default.
• W2078621572 creator A5090551729 @default.
• W2078621572 date "1995-04-01" @default.
• W2078621572 modified "2023-09-26" @default.
• W2078621572 title "Anti-beta 2-glycoprotein I antibodies: a marker of antiphospholipid syndrome?" @default.
• W2078621572 cites W1513897103 @default.
• W2078621572 cites W1766730806 @default.
• W2078621572 cites W1977490300 @default.
• W2078621572 cites W1984636261 @default.
• W2078621572 cites W1990942696 @default.
• W2078621572 cites W2000055469 @default.
• W2078621572 cites W2009197830 @default.
• W2078621572 cites W2011880796 @default.
• W2078621572 cites W2021306080 @default.
• W2078621572 cites W2025329539 @default.
• W2078621572 cites W2033322208 @default.
• W2078621572 cites W2040021911 @default.
• W2078621572 cites W2046838002 @default.
• W2078621572 cites W2093870776 @default.
• W2078621572 cites W2099836298 @default.
• W2078621572 cites W2100718758 @default.
• W2078621572 cites W2101831374 @default.
• W2078621572 cites W2113891001 @default.
• W2078621572 cites W2146203649 @default.
• W2078621572 cites W2160872701 @default.
• W2078621572 cites W2163702034 @default.
• W2078621572 cites W2322402935 @default.
• W2078621572 cites W2332313529 @default.
• W2078621572 doi "https://doi.org/10.1177/096120339500400208" @default.
• W2078621572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7795615" @default.
• W2078621572 hasPublicationYear "1995" @default.
• W2078621572 type Work @default.
• W2078621572 sameAs 2078621572 @default.
• W2078621572 citedByCount "149" @default.
• W2078621572 countsByYear W20786215722012 @default.
• W2078621572 countsByYear W20786215722013 @default.
• W2078621572 countsByYear W20786215722014 @default.
• W2078621572 countsByYear W20786215722015 @default.
• W2078621572 countsByYear W20786215722016 @default.
• W2078621572 countsByYear W20786215722017 @default.
• W2078621572 countsByYear W20786215722018 @default.
• W2078621572 countsByYear W20786215722019 @default.
• W2078621572 crossrefType "journal-article" @default.
• W2078621572 hasAuthorship W2078621572A5002803770 @default.
• W2078621572 hasAuthorship W2078621572A5005168112 @default.
• W2078621572 hasAuthorship W2078621572A5012925118 @default.
• W2078621572 hasAuthorship W2078621572A5030466896 @default.
• W2078621572 hasAuthorship W2078621572A5074400852 @default.
• W2078621572 hasAuthorship W2078621572A5079447134 @default.
• W2078621572 hasAuthorship W2078621572A5079468607 @default.
• W2078621572 hasAuthorship W2078621572A5087114501 @default.
• W2078621572 hasAuthorship W2078621572A5090551729 @default.
• W2078621572 hasConcept C108625454 @default.
• W2078621572 hasConcept C147483822 @default.
• W2078621572 hasConcept C153911025 @default.
• W2078621572 hasConcept C159654299 @default.
• W2078621572 hasConcept C185592680 @default.
• W2078621572 hasConcept C203014093 @default.
• W2078621572 hasConcept C2776874634 @default.
• W2078621572 hasConcept C2778918659 @default.
• W2078621572 hasConcept C2781302388 @default.
• W2078621572 hasConcept C41625074 @default.
• W2078621572 hasConcept C55493867 @default.
• W2078621572 hasConcept C71924100 @default.
• W2078621572 hasConcept C86803240 @default.
• W2078621572 hasConceptScore W2078621572C108625454 @default.
• W2078621572 hasConceptScore W2078621572C147483822 @default.
• W2078621572 hasConceptScore W2078621572C153911025 @default.
• W2078621572 hasConceptScore W2078621572C159654299 @default.
• W2078621572 hasConceptScore W2078621572C185592680 @default.
• W2078621572 hasConceptScore W2078621572C203014093 @default.
• W2078621572 hasConceptScore W2078621572C2776874634 @default.
• W2078621572 hasConceptScore W2078621572C2778918659 @default.
• W2078621572 hasConceptScore W2078621572C2781302388 @default.
• W2078621572 hasConceptScore W2078621572C41625074 @default.
• W2078621572 hasConceptScore W2078621572C55493867 @default.
• W2078621572 hasConceptScore W2078621572C71924100 @default.
• W2078621572 hasConceptScore W2078621572C86803240 @default.
• W2078621572 hasIssue "2" @default.
• W2078621572 hasLocation W20786215721 @default.
• W2078621572 hasLocation W20786215722 @default.
• W2078621572 hasOpenAccess W2078621572 @default.
• W2078621572 hasPrimaryLocation W20786215721 @default.
• W2078621572 hasRelatedWork W1565966142 @default.
• W2078621572 hasRelatedWork W194996653 @default.
• W2078621572 hasRelatedWork W2001143440 @default.
• W2078621572 hasRelatedWork W2036215861 @default.
• W2078621572 hasRelatedWork W2040191638 @default.
• W2078621572 hasRelatedWork W2046147253 @default.

• next